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The Genomics Landscape
In the July 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes the inaugural class of the ASHG-NHGRI Genomics and Public Service Fellowship Program.
… gene expression noise. They also found that the binding of transcription factors, proteins critically involved in the …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… of protein that helps turn genes on and off, known as a transcription factor. The STAT4 protein not only plays a role …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… genome, including epigenetic marks and sites occupied by transcription factors, primarily focusing on cell lines or … state (chromatin accessibility, histone modifications, transcription factor binding, DNA methylation and 3D … stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res , …
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
Staff
Dr. Brian Brooks is an adjunct investigator in NHGRI's Center for Precision Health Research.
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… have been shown to regulate chromatin state and transcription, and intron modifications may affect pre-mRNA … every cell. A major mediator of post-transcriptional gene regulation is the translating ribosome, which comprises three … are highly regulated, although the mechanisms of its regulation are poorly understood. A potential mechanism may …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… been previously implicated in CCEC. TAF1 encodes part of a transcription factor complex, which regulates the expression …
Educational Resources
Gene expression is the process by which the information encoded in a gene is used to direct the assembly of a protein molecule.
… gene is turned into a function. This mostly occurs via the transcription of RNA molecules that code for proteins or …
Staff
Dr. Stephanie Morris is a program director in NHGRI's Division of Genome Sciences.
… and Hager GL. Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor. Molecular and … Strahl BD. Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. …
Research Funding
The three research domains to be considered for support by the NHGRI Ethical, Legal and Social Implications Research Program.
… Genomics and the Rights of Individuals and Groups Law, Regulation and Policy Governing Genomics Industry, Commerce … examine system-level influences on: the direction and regulation of genomic science, research and technology … decision-making about the use of genomic information. Law, Regulation and Policy Governing Genomics The development and …