Search Results
Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
News Release
Researchers from the NHGRI-funded Impact of Genomic Variation on Function Consortium are exploring how genomic variation affects genome function.
… in regulating other genes and in various organs in mice. They also plan to understand these variants in female versus male mice and in mice with and without inflammation. The specific variants …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… functional studies of this locus in zebrafish and mice, researchers discovered that ZRANB3 plays a role in the …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… also the genomes of important research organisms, such as mice, C. elegans and zebrafish. Throughout the Human Genome …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… alleles in the vitamin B12 receptor, CD320, in humans and mice. (Molecular Basis of Mendelian Disorders) 2819W. … carriers. (Metabolic Disorders) *2313T. Peter J. McGuire: Mice lacking Cox10 in T-lymphocytes recapitulate the immune … c. 49G>A, p. Glu17Lys causes embryonic lethality in mice. (Molecular Basis of Mendelian Disorders) 11:45-12:45 …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
​
… in basic research. Editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly … [1] Capecchi, M. R. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the …
Staff
Dr. Francis Collins was a senior investigator in Center for Precision Health Research.
… the disease seen in HGPS patients. Specifically, these mice exhibit progressive loss of vascular smooth muscle cells … prevented the onset of cardiovascular disease in young mice but also reduced the progression of the cardiovascular defects upon treatment of older mice. This research complemented other data in support of a …
News Release
ENCODE program directors in the Division of Genome Sciences turned to Reddit to answer questions from the Reddit community.
… in the mouse, we got what looked like viable 'normal' mice. We were expecting the mice to die or have some sort of selective phenotype we could …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… to all three. A knockout mouse model (genomically altered mice that are bred to lack a specific gene) displayed a … muscle development, leading to early death of the newborn mice, making this gene a promising candidate for further …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… 1979, researchers produced the first genetically identical mice by splitting mouse embryos in the test tube and then … the resulting embryos into the wombs of adult female mice. Shortly after that, researchers produced the first … cell division. In other mammals, such as cats, rabbits and mice, the two spindle proteins are spread throughout the egg. …