Search Results
The Genomics Landscape
In the April 2024 issue of The Genomics Landscape, NHGRI Director Eric Green details how the Office of Genomic Data Science (OGDS) is becoming the epicenter for genomic data science at the institute, with numerous collaborations, projects and activities.
… report that proposes expanded efforts to better understand RNA, DNA’s sister molecule. RNA is responsible for many cellular functions, including … in DNA into the proteins necessary for life. Despite RNA’s numerous important roles in human health, many … NASEM releases report proposing expanded studies of RNA …
For Teachers
Lesson plan based on an award-winning DNA from the Beginning website, an animated primer on the basics of DNA, genes and heredity.
… of tubes 1-4 look like to illustrate this finding? #21. RNA is an intermediary between DNA and protein. What is the … read an autoradiogram of a gene sequencing gel? #24. The RNA message is sometimes edited. What happens to mRNA when … detect the exon regions on an electron micrograph of a DNA/RNA hybrid? #25. Some viruses store genetic information in …
Staff
Dr. Daniel Gilchrist is a program director of Computational Genomics and Data Science in NHGRI's Division of Genome Science.
… GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and … G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome … S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. …
News Release
Genome: Unlocking Life's Code exhibition is going on tour after having completed a 14-month engagement at the Smithsonian's National Museum of Natural History.
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… silencing or activation of messenger RNAs, long noncoding RNA and a host of other regulatory elements such as enhancers … neurodevelopmental disease and cancer. Center for Dynamic RNA Epitranscriptomes RM1 HG008935 Chuan He University of Chicago Chemical modifications on mammalian messenger RNA (mRNA) have recently been shown to play critical and …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
… in the lab. 4 With CRISPR, researchers create a short RNA template that matches a target DNA sequence in the genome. Creating synthetic RNA sequences is much easier than engineering proteins as is those required for ZFNs and TALENs. Strands of RNA and DNA can bind to each other when they have matching …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… DNA, a synthetic type of DNA generated from messenger RNA, or mRNA, the molecule in the cell that takes information … how large numbers of genes are expressed as messenger RNA in a particular tissue, and how a cell's regulatory … the structural components, or building blocks, of DNA and RNA. A nucleotide consists of a base chemical - either …
News Release
Six new grants will support researchers for new computational approaches to search millions of genomic variants for disease susceptibility.
… not translated into proteins, they may be transcribed into RNA. Such RNA carries out various regulatory functions in a cell. The researchers have shown that disrupting RNA structure can lead to diseases in people, including an …
Event
We invite scholars to submit ideas to be one of six to seven speakers at our symposium, “Irreducible Subjects: Disability and Genomics in the Past, Present, and Future”, with an additional opportunity to join a collected set of papers on the same theme.
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… molecule in the form of nucleic acids such as DNA or RNA. a protein layer, or coat, that surrounds and protects … can cause disease. Viruses that encode information with RNA rather than DNA tend to have a higher rate of mutations. … an organism's entire nucleic acid material (such as DNA or RNA), which is known as its genome. In 1977, researchers …