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Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… somatic mutations in PI3-kinase in endometrial tumors, thus uncovering previously unrecognized cohorts of … alterations that drive clinically aggressive endometrial tumors, and to understand their functional consequences. Dr. … the genetic and genomic alterations that drive solid tumors. In her previous position at Massachusetts General …
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …
Fact Sheet
With increasing complexity in genomic data, researchers are turning to artificial intelligence and machine learning as ways to identify meaningful patterns for healthcare and research purposes.
… patterns and critical information by imitating how a human brain’s neurons interact with each other. The algorithms are … neural networks — a computing system that simulates the brain’s ability to weigh the importance of some data versus …
National Advisory Council for Human Genome Research
The Director's Report Related documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in February 2020.
… of Us News, Events, and Media Website 5 New Director, NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Dr. John Ngai named director of NIH BRAIN Initiative NIH BRAIN Initiative Website NIH BRAIN …
Staff
Dr. Sudre is an Associate Investigator in Dr. Philip Shaw's Neurobehavioral Clinical Research within the Social and Behavioral Research Branch
… at Carnegie Mellon University investigating how the human brain represents information. More specifically, they looked for semantic information in the brain while subjects perform several cognitive tasks and used … with machine learning techniques to classify different brain states. Previously, Dr. Sudre was part of the Human …
Genetic Disorders
Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that affects a person's ability to control their behavior and pay attention to tasks.
… are: 1) familial: ADHD often runs in families; 2) abnormal brain development; or 3) brain injuries occuring before, during or after birth. … Brain images of children with ADHD may show differences …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… identified, clinicians may be able to treat patients whose tumors have specific gene changes with drugs currently …
Staff
Dr. Philip Shaw was an investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… environmental factors that influence the development of brain and behavior. A focus of his work was the most common … factors in shaping the developmental trajectories of brain and behavior. The program focused on one of the most … to behavioral processes that can be mapped directly onto brain structure and function. The work linking brain …
For Patients and Families
​Pharmacogenomics combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics.​
… (Herceptin). This therapy works only for women whose tumors have a particular genetic profile that leads to … (Tarceva), work much better in lung cancer patients whose tumors have a certain genetic change. On the other hand, … very well in the 40 percent of colon cancer patients whose tumors have a particular genetic change. Pharmacogenomics may …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… of a gene called GATA2, a gene known to be important for brain stem development. These findings demonstrate the …