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News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… you could figure out patterns of toxicity of potential new drug compounds by looking at cellular responses and finding … responses to drugs was more accurate than conventional drug-potency tests. This recognition may point the way toward … and diseased human cells. Dr. Sorger hopes that future drug developers will be able to perform computations on LINCS …
Office of Genomic Data Science
NHGRI is committed to increasing the availability of educational and research opportunities in computational genomics and data science (CGDS).
… burdened by disparities in health status and health care delivery, including racial and ethnic minority groups, …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… account a person's genetic information regarding specific drug receptors and how drugs are transported and metabolized … goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs. One example is the breast cancer drug trastuzumab (Herceptin). This therapy works only for …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… hope was based on the success of imatinib (Gleevec), a drug that was specifically designed to treat a blood cancer … in many CML patients. Unfortunately, the one-target, one-drug approach has not held up for most other types of cancer. … pathways and the genetic profiles of particular tumors, drug developers might be able to focus their attention on …
Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
… evaluating insertion profiles of standard and novel gene delivery methods. A goal of this work is to find ways to …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Such high-throughput screening has identified thousands of drug candidates over the past 10 years but has resulted in …
File
… and through descriptions of best practices for the delivery of genomic medicine. 2) Education: Provide education … ACMG has entered into an agreement with the US Food and Drug AdministrationÕs Center for Devices and Radiologic … genetic services across the lifespan and across healthcare delivery systems. At the time of the rollout of the ACA and …
News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… to genomics: " pinpoint gene editing ," " a cancer drug's broad swipe ," and " gene therapy triumph ." Nature's …
Genetic Disorders
Crohn's disease is a chronic inflammatory disorder of the bowel, usually diagnosed in people between the ages of 20 - 30.
… such as abdominal pain, diarrhea and rectal bleeding. Drug therapy for Crohn's disease includes: Anti-inflammation … system suprressors, such as 6-mercaptopurine or a related drug, azothioprine. Infliximab (Remicade), a drug that is the first of a group of medications that blocks …