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The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… elements, which act as “switches” to regulate gene transcription. The ENCODE findings point to millions of … insights into the DNA modifications that influence genome function, the proteins that bind to DNA, and how RNA molecules interact to regulate gene expression. The results reported in the ENCODE 3 …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… DNA sequences near genes that control when and how much a gene is turned on and off, or expressed, are often extremely important for gene activity. … To paint a clearer picture of how such variation affects gene activity, Fernando Pardo Manuel de Villena, Ph.D., at …
Genetic Disorders
Fragile X syndrome is an inherited intellectual disability caused by a mutation in the FMR1 gene.
… intellectual disability caused by a mutation in the FMR1 gene. … are caused by an alteration (mutation) in the FMR1 gene where a DNA segment, known as the CGG triplet repeat, is … expanded CGG segment inactivates (silences) the FMR1 gene, which prevents the gene from producing a protein called …
Fact Sheets
Genetic mapping offers evidence that a disease transmitted from parent to child is linked to one or more genes and clues about where a gene lies on a chromosome.
… and provides clues about which chromosome contains the gene and precisely where the gene lies on that chromosome. … tools to identify new genes and to understand their function. One of these tools is genetic mapping. Genetic … also provides clues about which chromosome contains the gene and precisely where the gene lies on that chromosome. …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… result in some changes to how NIH staff members function, as (like for many aspects in society) we begin … normally and identifying the factors that disrupt normal function is a central challenge in biomedical research. To … Novartis) have created their own LINCS-related low-cost gene-profiling technologies, and Novartis has even leveraged …
Educational Resources
Genomics refers to the study of the entire genome of an organism whereas genetics refers to the study of a particular gene.
… whereas genetics refers to the study of a particular gene. … Genomics, Genes, Gene Expression, Human Genome Project … whereas genetics refers to the study of a particular gene. …
Educational Resources
Codominance is a relationship between two versions of a gene.
… Codominance is a relationship between two versions of a gene. … of inheritance in which two versions (alleles) of the same gene are expressed separately to yield different traits in an … Codominance is a relationship between two versions of a gene. …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… Transcription is the process of making an RNA copy of a gene sequence. … Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), Nuclear Membrane, … to genomics, is the process of making an RNA copy of a gene’s DNA sequence. This copy, called messenger RNA (mRNA), …
Educational Resources
An oncogene is a mutated gene that contributes to the development of a cancer.
… An oncogene is a mutated gene that contributes to the development of a cancer. … Mutagen, Cancer, Cell, Mutation, Tumor Suppressor Gene … An oncogene is a mutated gene that has the potential to cause cancer. Before an … An oncogene is a mutated gene that contributes to the development of a cancer. …
Educational Resources
Sex linked is a trait in which a gene is located on a sex chromosome.
… Sex linked is a trait in which a gene is located on a sex chromosome. … Cell, Mutation, Gene, Sex Chromosome … Sex linked is a trait in which a gene is located on a sex chromosome. …