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The Genomics Landscape
In the July 2023 edition of The Genomics Landscape, NHGRI Director Eric Green describes the evolution of the NHGRI Intramural Research program over the last three decades talks about its future in conducting truly exceptional basic, translational, and clinical genomics research.
… by many genetic factors and disease development.  This research was funded by NIH with a grant to Steven Henikoff, … Hutchinson Cancer Center; that grant is part of the NIH Research Project Grant Program ( PA-18-484 ). … by the recent addition of the Future Leaders Advancing Genomic Sciences and Health Innovation (FLAGSHIP) …
Fact Sheet
Several regulations and policies stipulate the information that must be given to research participants prior to their enrolling in a study.
… The Big Picture:  Informed consent is crucial in research as it ensures individuals have an informed choice about whether to participate in a research study.  In the United States, the requirements for obtaining informed consent from research participants are stipulated by several regulations …
The Informed Consent Resource
Explore the basic elements of informed consent that are required by the Common Rule and that are relevant to genomics.
… Regulations require "a statement that the study involves research, an explanation of the purposes of the research..." … involves research, why they have been approached about participation, and who is sponsoring the project. This … topics such as a brief description of the underlying genomic science, the study design, the diseases(s) or …
Research Funding
Frequently asked questions for Investigator-Initiated Research on Genetic Counseling Processes and Practices FOAs (RFA-HG-20-048 and RFA-HG-20-049).
… experience need(s) to be an integral part of the research team including being involved in research design, … applications that enhance genetic counseling strategies in genomic medicine which involves including genetic information … may be proposed as long as it is broadly applicable to genomic medicine as a field (see related question #6).  If …
For Patients and Families
​Clinical research is research conducted with human subjects, or material of human origin, in which the researcher directly interacts with human subjects.
… Clinical research is research conducted with human subjects, or material of human … Clinical researchers at the National Human Genome Research Institute (NHGRI) are developing advanced methods … Clinical research is research conducted with human subjects, or material of human …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… of nearly 20 papers published online in 2014 highlights research on the use of DNA biorepositories and electronic … Network. eMERGE is supported by the National Human Genome Research Institute (NHGRI), part of the National Institutes … patient's data and disease characteristics with his or her genomic information collected from stored tissue specimens in …
Clinical Research
A study for patients with unexpected genetic results
… The Genomic Services Research Program (GSRP) is a study of people with "secondary … result, please consider partnering with us on this research. Together we hope to understand the health impacts … May 13, 2021: From one genomic diagnosis, researchers discover other treatable …
The Genomics Landscape
In the October 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, reflects on the twelve years of groundbreaking research by the Clinical Sequencing Evidence-generating Research (CSER) consortium.
… in traits, including the risk for disease. Some genomic variants are small, like changes to single letters of … cancer, respectively, compared to previously identified genomic variants. These findings suggest a potentially … significant role of VNTRs in human traits.  This research was funded by NIH through a grant to Steven …
Research Funding
Policies and guidance regarding research funding from the NHGRI and the National Institutes of Health.
… federal agency responsible for biomedical and behavioral research and research training. As such, it is accountable to Congress and … the general public for responsible stewardship of federal research dollars. Sound management of research funds requires … Policies and guidance regarding research funding from the National Human Genome Research …
The Genomics Landscape
In the September 3, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about the Impact of Genomic Variation on Function (IGVF) Consortium, the 2020 Genomic Innovator Awards and more.
… and I answered questions about bioethics and genomics research on Twitter as part of #AskDrGenome . Meanwhile, the … meeting of the National Advisory Council for Human Genome Research will take place on September 14-15. As usual, the … at 11:30 a.m. EST to hear updates about NHGRI and genomics research more broadly. …