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News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… and genetic factors - that are potentially disruptive to cells. LINCS researchers then will measure the cells' tiniest molecular and biochemical responses, and use … signatures, using human heart, liver and nerve cells from stem cells that have been derived from human skin cells. Such …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… being written and rewritten by the cancer's rogue cells. Untangling the genetic influences on these rules will … analyses. This allowed the team to study the cancer cells' genome. A genome can be thought of as a huge DNA … (the chapters), and provides all the instructions for our cells to do their jobs. Because cancer cells have many …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… edited the disease-causing mutation in blood-forming cells taken directly from people with sickle-cell disease. …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… Medicine that they have succeeded in coaxing cultured cells to exhibit the signature traits of the disease. Using … that has successfully corrected the malfunctioning cells. … Second, they reprogrammed patients' skin cells to become stem cells, which could then be differentiated into …
Fact Sheet
Sickle cell disease resources for healthcare providers
Talking Glossary
Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell.
… (including humans), chromosomes reside in the nucleus of cells. Humans have 22 pairs of numbered chromosomes …
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… or plant. In animals, female gametes are called ova or egg cells, and male gametes are called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… when two genetic neighborhoods merge in brain tumor cells. Researchers found that one gene came under the control … IDH gene was mutated, particular portions of the cancer cells' DNA became studded with chemical tags called methyl … of these genetic neighborhoods, a gene called PDGFRA makes cells grow, or increase in number, but is rarely turned on. …
Educational Resources
Bacteria are small single-celled organisms.
… and in fact is estimated to contain more bacterial cells than human cells. Most bacteria in the body are harmless, and some are …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… of DNA and other molecules that may be retained as cells divide to make more cells. … of DNA and other molecules that may be retained as cells divide to make more cells. When found in DNA, methylation can alter gene … of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of …