Search Results
Staff
Dr. Heidi Sofia served as a program director in the Division of Genomic Medicine at the National Human Genome Research Institute from 2010-2023.
… Dr. Heidi Sofia joined NHGRI in 2010 as part of the team responsible for The Cancer Genome Atlas (TCGA) initiative in cancer genomics, jointly managed by NHGRI and the National … Hutter C, Getz G, Wheeler D, Ding L, MC3 Working Group, Cancer Genome Atlas Research Network. Scalable open science …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… Epigenomics is a field in which researchers chart the locations and understand the … the proteins that carry out a variety of functions in a cell. The epigenome is made up of chemical compounds and … genes on or off, controlling the production of proteins in particular cells.When epigenomic compounds attach to DNA …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … a protein that acts to regulate cell division, keeping it in check. When a tumor suppressor gene is inactivated by a … Such mutations may contribute to the development of a cancer. …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… Genes, Cancer, Heart Disease, Gene-environment Interactions … A complex disease (or condition), when discussed in the context of genetics, reflects a disorder that results … the contributions of multiple genomic variants and genes in conjunction with significant influences of the physical …
Educational Resources
A mutagen is a chemical or physical phenomenon, such as ionizing radiation, that promotes errors in DNA replication.
… such as ionizing radiation, that promotes errors in DNA replication. … Mutagen, DNA Mutation, DNA Replication, Cancer … a chemical or physical agent capable of inducing changes in DNA called mutations. Examples of mutagens include tobacco … such as ionizing radiation, that promotes errors in DNA replication. …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… Gene amplification is an increase in the number of copies of a gene sequence. … DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, Laboratory Experiment … an increase in the number of copies of a gene in a genome. Cancer cells, for example, sometimes produce multiple copies …
Event
NHGRI, National Institute of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) will host a pre-application interactive webinar for the Multi-Omics for Health and Disease program funding opportunity announcements (FOAs): RFA-HG-22-008,
RFA-HG-22-009 and RFA-HG-22-010.
… during the webinar and are encouraged to email questions in advance to MultiOmicsProgram@mail.nih.gov . … of Environmental Health Sciences (NIEHS) and National Cancer Institute (NCI) will host a pre-application … Center (U01 Clinical Trial Not Allowed) All times in ET. …
Educational Resources
Apoptosis is the process of programmed cell death.
… Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … example, those between the fingers of a developing hand. In adults, apoptosis is used to rid the body of cells that … beyond repair. Apoptosis also plays a role in preventing cancer. If apoptosis is for some reason prevented, it can …
Educational Resources
Gene therapy is an experimental technique for treating disease by altering the patient's genetic material.
… Genetic Disease, Genetic Disorder, Gene Mutation, Cancer Treatment, Healthcare … is broken, or by replacing a defective or missing gene in a patient’s cells with a healthy version of that gene. …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… A key challenge health care providers face in treating prostate cancer is distinguishing the aggressive, potentially … Findings from the study were published April 15 online in The American Journal of Human Genetics . "The genomic … way to identify a specific subgroup of prostate cancer tumors with a known treatment option," said Elaine …