Search Results
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted … gene therapy for humans. Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, published … an association between AAV and the occurrence of liver cancer. The present research addresses this problem in gene …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … “signatures” that reflect the responses that different cell types show under different conditions. LINCS was based … cellular characteristics, behavior, and/or function of a cell. In the past, most research studies designed to …
News Release
NIH grants aim to gauge if genomics can be used to help diagnose diabetes, manage heart disease and guide cancer clinicians to the most effective drugs.
… keep heart disease patients out of hospitals and guide cancer clinicians and patients to the most effective drugs. … (IGNITE) program administered by the National Human Genome Research Institute (NHGRI), part of NIH. All three … on genomically guided prescriptions of cardiovascular and cancer drugs. David Flockhart, M.D. , Ph.D. , Indiana …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS) study is exploring sickle cell disease in adults by looking at many factors, including … factors influence the onset and development of sickle cell leg ulcers. While leg ulcers are a primary focus of this …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… on Genomics and Global Health (CRGGH), have used whole genome sequence data to investigate the origin of the … of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This … Researchers used whole genome sequence data to investigate the origin of the …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… is a collection of all the gene readouts present in a cell. … The human genome is made up of DNA (deoxyribonucleic acid), a long, … is a collection of all the gene readouts present in a cell. There are various kinds of RNA. The major type, called … to ribosomes , the molecular machines located in the cell's cytoplasm; then the ribosomes read, or "translate," …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… (NIH) have discovered the genomic switches of a blood cell are key to regulating the human immune system. The … micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Source: … M.D., Nicholas P. Restifo, M.D., at the NIH's National Cancer Institute, and Yijun Ruan, Ph.D., at The Jackson …
News Release
Researchers identified regions of the genome associated with skin color variation in some African populations, furthering skin disease and cancer research.
… researchers has identified new regions of the human genome that are associated with skin color variation in some … opening new avenues for research on skin diseases and cancer in all populations. … from these regions is thought to reduce skin damage and cancer. In contrast, lighter pigmentation of people in …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
… The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes. … Messenger RNA (mRNA), Ribonucleic Acid (RNA), Translation, Cell, Cytoplasm, Protein, Nucleus, Ribosome … The nucleolus is a spherical structure found in the cell’s nucleus whose primary function is to produce and …
Educational Resources
A nucleus is a membrane-bound organelle that contains the cell's chromosomes.
… A nucleus is a membrane-bound organelle that contains the cell's chromosomes. … Chromosome, Cell, Deoxyribonucleic Acid (DNA) … to genomics, is the membrane-enclosed organelle within a cell that contains the chromosomes. An array of holes, or … A nucleus is a membrane-bound organelle that contains the cell's chromosomes. …