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The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … “signatures” that reflect the responses that different cell types show under different conditions. LINCS was based … cellular characteristics, behavior, and/or function of a cell. In the past, most research studies designed to …
News Release
NIH grants aim to gauge if genomics can be used to help diagnose diabetes, manage heart disease and guide cancer clinicians to the most effective drugs.
… keep heart disease patients out of hospitals and guide cancer clinicians and patients to the most effective drugs. … (IGNITE) program administered by the National Human Genome Research Institute (NHGRI), part of NIH. All three … on genomically guided prescriptions of cardiovascular and cancer drugs. David Flockhart, M.D. , Ph.D. , Indiana …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… is a collection of all the gene readouts present in a cell. … The human genome is made up of DNA (deoxyribonucleic acid), a long, … is a collection of all the gene readouts present in a cell. There are various kinds of RNA. The major type, called … to ribosomes , the molecular machines located in the cell's cytoplasm; then the ribosomes read, or "translate," …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… on Genomics and Global Health (CRGGH), have used whole genome sequence data to investigate the origin of the … of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This … Researchers used whole genome sequence data to investigate the origin of the …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… (NIH) have discovered the genomic switches of a blood cell are key to regulating the human immune system. The … micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Source: … M.D., Nicholas P. Restifo, M.D., at the NIH's National Cancer Institute, and Yijun Ruan, Ph.D., at The Jackson …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
… The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes. … Messenger RNA (mRNA), Ribonucleic Acid (RNA), Translation, Cell, Cytoplasm, Protein, Nucleus, Ribosome … The nucleolus is a spherical structure found in the cell’s nucleus whose primary function is to produce and …
News Release
Researchers identified regions of the genome associated with skin color variation in some African populations, furthering skin disease and cancer research.
… researchers has identified new regions of the human genome that are associated with skin color variation in some … opening new avenues for research on skin diseases and cancer in all populations. … from these regions is thought to reduce skin damage and cancer. In contrast, lighter pigmentation of people in …
Educational Resources
A nucleus is a membrane-bound organelle that contains the cell's chromosomes.
… A nucleus is a membrane-bound organelle that contains the cell's chromosomes. … Chromosome, Cell, Deoxyribonucleic Acid (DNA) … to genomics, is the membrane-enclosed organelle within a cell that contains the chromosomes. An array of holes, or … A nucleus is a membrane-bound organelle that contains the cell's chromosomes. …
Educational Resources
A centrosome is a cellular structure involved in the process of cell division.
… is a cellular structure involved in the process of cell division. … Cell Division, Basic Biology, Nucleus … is a cellular structure involved in the process of cell division. Before cell division, the centrosome duplicates and then, as … is a cellular structure involved in the process of cell division. …
Educational Resources
A nuclear membrane is a double membrane that encloses the cell nucleus.
… A nuclear membrane is a double membrane that encloses the cell nucleus. … Nuclear Membrane, Chromosome, Cell Biology … The nuclear membrane is a double layer that encloses the cell’s nucleus, where the chromosomes reside. The nuclear … membrane serves to separate the chromosomes from the cell’s cytoplasm and other contents. An array of small holes …