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The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… approach of using the best-available technologies for sequencing DNA and pushing them to their absolute limits. In … filling in the remaining bits because the technologies for sequencing DNA at that time were clearly not up to the task. … Project, more powerful technologies, such as long-read DNA sequencing methods and newer computational tools, aided …
Educational Resources
A restriction enzyme is an enzyme isolated from bacteria that cuts DNA molecules at specific sequences.
… Bacteria, Deoxyribonucleic Acid (DNA), Enzyme, Genetic Engineering, Recombinant DNA …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it … Eric Green, proposed the idea of establishing a DNA sequencing center at NIH to Francis Collins and Jeff Trent … joined forces with NHGRI to establish the NIH Intramural Sequencing Center (NISC) in the fall of 1997. . . and the …
Educational Resources
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means.
… Cell, Cloning, Deoxyribonucleic Acid (DNA), Gene, Germ Line …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… Deoxyribonucleic Acid (DNA), Gene Amplification, Hybridization, Polymerase … in a very short timeframe. Primers are also used in DNA sequencing and other experimental processes. …
Staff
Dr. James Thomas is the acting director for the NIH Intramural Sequencing Center (NISC).
… Dr. James Thomas is the director of the NIH Intramural Sequencing Center. He oversees the importation and use of DNA sequencing technologies, protocols and analyses, ensuring … that NIH investigators have access to cutting-edge DNA sequencing methods and specialized genomics protocols to meet …
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will … NHGRI to Intramural Investigators employing exome/genome sequencing. ​ … DNA Sequencing, Exam Sequencing, Genome Sequencing, Secondary Findings, Genetic …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… The National Institutes of Health will fund a set of genome sequencing and analysis centers whose research will focus on … for Common Disease Genomics (CCDG), which will use genome sequencing to explore the genomic contributions to common … cystic fibrosis and muscular dystrophy. "Advances in DNA sequencing are creating tremendous new opportunities for …