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Staff
Dr. Edward Giniger is an adjunct investigator in NHGRI's Genetics and Molecular Biology Branch.
… Information processing in the brain is done by specialized neural circuits. Every neuron … almost certainly acts in construction of the human brain and nervous system. … Giniger, E. How do Rho family … in mushroom body neurons of the Drosophila central brain. J. Neurosci . 31:10451-62. 2011. [PubMed] Gates, M.A., …
Staff
Dr. Eggerton Campbell is a senior licensing and patenting manager in the Technology Transfer Office at the National Human Genome Research Institute.
… nucleic acid amplification (PCR), detection of tumors/cancer via mutations, recombinant polypeptides, human …
Media Availability
New research provides a better understanding of some of the genetic and cellular changes in pathways and processes involved in Autism Spectrum Disorder.
… Synapses are the spaces between nerve cells over which brain messages must travel. Mutations in synaptic genes and … on and off, and the formation of neural connections in the brain. Transcription. Instructions embedded in genes must be … can affect a wide range of important processes in the brain, from controlling gene activity to transmitting …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… biological pathways and the genetic profiles of particular tumors, drug developers might be able to focus their … likely to repair the pathways affected in their particular tumors. … How do biological pathways work? … What are some …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… of mice and examined regulatory DNA and gene activity in brain and other tissue. They found that more than 80 percent … parent, they found that expression in 95 genes in the brain depended more on being inherited from one parent than … unexpectedly discovered that for thousands of genes in the brain, there was a slightly greater expression of genes …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… and complex trait mapping and genomic analysis of canine tumors. The primary goal of Dr. Parker’s research is to use … and shared regions of dysregulation with human bladder tumors . BMC Cancer 24;20(1):251, 2020. Parker HG*, Whitaker …
News Release
NIH researchers have identified and tested a molecule that shows promise as a possible treatment for Gaucher disease and Parkinson's disease.
… to treat Gaucher disease have not been able to enter the brain and reach those neurons that are affected in the most … ) is the nation's leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce …
Staff
Dr. Acosta is a board-certified pediatric neurologist with the NIH Undiagnosed Diseases Program's GM1 gene therapy trial.
… using interspecies comparisons of clinical outcomes and brain connectivity changes using r-fMRI techniques. As … our intervention using traditional and novel techniques in brain MRI- including structural, magnetic resonance … (NCT02461420); and the “Autoimmune Brain Disorders Program” lead by Dr. Gena Mooneyham at NIMH. …
News Release
Researchers funded by NHGRI’s Genome Technology Program include a wide range of investigators with a variety of scientific expertise.
… , to probe intricate cellular details of the mouse brain and how immune cells change in different environments …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… system and can cause abnormal eye movements, seizures and brain damage. Current treatments often involve enzyme … this infused form of the enzyme cannot cross into the brain and treat the symptoms of the disease that affect the …