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The Genomics Landscape
In the April 2024 issue of The Genomics Landscape, NHGRI Director Eric Green details how the Office of Genomic Data Science (OGDS) is becoming the epicenter for genomic data science at the institute, with numerous collaborations, projects and activities.
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Such high-throughput screening has identified thousands of drug candidates over the past 10 years but has resulted in …
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Researchers developed a technique that will aid in a more accurate reconstruction of human genomes.
News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
Genetic Disorders
Crohn's disease is a chronic inflammatory disorder of the bowel, usually diagnosed in people between the ages of 20 - 30.
… such as abdominal pain, diarrhea and rectal bleeding. Drug therapy for Crohn's disease includes: Anti-inflammation … system suprressors, such as 6-mercaptopurine or a related drug, azothioprine. Infliximab (Remicade), a drug that is the first of a group of medications that blocks …
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Researchers from NHGRI, Oxford University and other National Institutes of Health centers have developed and tested a new method to predict hospital-acquired infections involving five other important pathogens.
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… – two conditions where finding safe and effective drug treatments have been difficult. Because there are few … makeup helps determine how they will respond to certain drug treatments. In pharmacogenomics, information about a … makeup helps determine how they will respond to certain drug treatments. These projects build upon the first phase of …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… from generation to generation. Clinical trials of drugs: Drug testing includes classes of drugs that control symptoms, … found an effective way to slow or prevent the disease. The drug used by UC Irvine researchers to prevent the cell death … cancer in humans. This could speed up human trials of the drug in Huntington's disease patients. …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… curtail a gene's activities. Researchers identified two drug-metabolizing variants tied to three TPMT alleles. The …
News Release
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure.
… is regulated. Such insights could point to potential new drug targets. “Our study helps explain a much larger … discovered in the study may also have the potential to be drug targets to alter blood pressure.  Our study helps … studies have clinical relevance for finding new drug targets and are needed to discover more drug targets as …