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News Release
Six new grants will support researchers for new computational approaches to search millions of genomic variants for disease susceptibility.
… understand the DNA drivers of common human diseases (using immune diseases as test cases), the researchers plan to … analyze how DNA variants that are associated with common immune diseases cause individuals to differ in their immune … that contribute to human disease. They plan to test a system they developed called Combined Annotation Dependent …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… of the evolutionarily ancient innate branch of the human immune system. Dr. Kastner has won a number of awards and honors, … autoinflammatory disease to denote a broad group of innate immune disorders. Based on other clinical encounters, the … phospholipase Cγ2-associated antibody deficiency and immune dysregulation (PLAID), a separate autoinflammatory …
News Release
Researchers from NHGRI and the Undiagnosed Diseases Program (UDP) have discovered a new neurological condition characterized by issues with motor coordination and speech.
… could provide insights into how the cell’s recycling system contributes to a healthy brain. …
News Release
Three research teams funded by NIH gather data at the most basic molecular levels about the biological processes that make up the human microbiome.
… production, protection against invading pathogens and immune system support. Now, the number of bacterial species living … and possibly trigger onset of disease linked to the immune system. Such stressors could particularly affect …
Staff
Dr. Lanata is a staff clinician in NHGRI's Genomics of Autoimmune Rheumatic Disease Section.
… I, Jain TS, Nititham J, et al. Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… disorder (a condition that occurs when the body's immune system attacks normal, healthy body tissue). However, no …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… network models, taking advantage of the dynamics of the system as the cells transition from one physiologic state to … PI(s) Institution Study Title (RePORTER Link) Biological System Alexander Hoffmann, Ph.D. and Douglas Black, Ph.D. … Angeles "Ribonomics" Of Gene Regulation To Predict Innate Immune Responses Post-transcriptional response to pathogens, …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… Genomics Research NIH Researchers Link Graying Hair and the Immune System Essential Malaria Parasite Genes Revealed Genomic … NIH Study Finds Gut Microbiome Can Control Antitumor Immune Function in Liver One Patient's Diagnostic Odyssey …
News Release
NIH will support research that incorporates DNA sequence information into electronic medical records.
… high neutrophil count can signal a disorder involving the immune system. They will use DNA sequencing to examine the genetic … are associated with cardiovascular, neuropsychiatric and immune-mediated conditions described in electronic medical …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… pathogens. This evolutionary battle is between the human immune system and microorganisms trying to invade our bodies. … response of the body. Pyrin is activated when there is an immune response (for example, in the event of an infection). …