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… have benefited from the creation and management of large, interdisciplinary 127 research collaborations. 128 … data that 250 8 keep pace with the generation of large and multidimensional datasets are needed; such 251 … 434 435 Enable the routine generation and use of synthetic nucleic acids in genomics 436 research. The …
Educational Resources
Polymerase chain reaction (PCR) is a laboratory technique used to amplify DNA sequences.
… be studied in greater detail. PCR involves using short synthetic DNA fragments called primers to select a segment of …
File
… ed a concept for three RFAs: Nucleic Acid Sequencing , Synthetic Nucleic Acids , and a Coordinating Center RFA . The … and novel clinical application s. The goal of the new Synthetic Nucleic Acids RFA is to produce cheaper, more accurate , and longer oligonucleotide s and very large synthetic constructs of double strand DNA with base …
Event
NHGRI hosts a virtual Q&A with science journalist Angela Saini, author of “Superior: The Return of Race Science” on Thursday, July 23, 2020.
Genetic Disorders
Duchenne muscular dystrophy is a rapidly progressive form of muscular dystrophy caused by a mutation in the DMD gene.
… changing, but the methods currently being used look for large changes in the gene ( deletion/duplication ) and … blood pressure, behavior changes, and delayed growth. A synthetic form of prednisilone, called Deflazacort, is used …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
News Release
As researchers uncover millions of DNA differences in genes, doctors struggle to know which of these inherited differences, called variants, really matter.
… researchers, clinicians and genetic testing laboratories. "Large-scale sequencing of whole genomes today often means …
Fact Sheet
Sickle cell disease resources for patients
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… humans physiologically, its genome contains a surprisingly large number of genes. Piwi1-positive spermatogonia are shown … humans physiologically, its genome contains a surprisingly large number of genes that are like human disease genes, …
Research Funding
The Genome Technology Program is refining current technologies to increase efficiency and decrease cost while maintaining or improving data quality.
… and genotyping along with epigenetic, functional, and synthetic genomics experiments. The development of completely … R21: RFA-HG-21-007 R43/R44: RFA-HG-21-008 Novel Synthetic Nucleic Acid Technology Development R01: …