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Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… studies of cultured cells, bacteria, fruit flies, mice and other organisms. Many of the pathways identified in …
The Genomics Landscape
In the April 2020 edition of The Genomics Landscape, NHGRI Director Eric Green provides an update on the final stage of the Genomics2020 strategic planning process; the NIH website for COVID-19 information, the Gene documentary debut on PBS and more.
… COVID-19 Gene mutation enhances cognitive flexibility in mice, NIH study suggests NIH researchers discover gene for …
News Release
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… They do not seem to be valid across species, such as in mice, dogs, and wolves. To see why the epigenetic clocks in …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… of the disease by breeding laboratory animals, such as mice, and attempting to duplicate the clinical features of …
File
… to inactivate or Òknock-outÓ any partic- ular gene in mice bred for this purpose, and this is proving an extremely … For example, vectors have been designed to deliver transgenic DNA into the 66 Genomics and World Health plant … is the production of hepati- tis B surface antigen in transgenic plants for oral immunization. Similarly, a trial …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… such β-cell death, the researchers took β-cell cells from mice and performed a similar knockdown of the ZRANB3 gene as …
The Genomics Landscape
In the November 2019 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the International Common Disease Alliance's scientific plenary and launch meeting in September, which included an international panel on opportunities emerging outside the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, data sharing, and ethics.
… Schizophrenia risk gene linked to cognitive deficits in mice Scientists unveil search-and-replace genome editing …
Staff
Dr. Brian Brooks is an adjunct investigator in NHGRI's Center for Precision Health Research.
… WJ. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Inv Ophthal Vis Sci , 48:3905-13. 2007. [ PubMed ] Alur …
Staff
Dr. James Thomas is the acting director for the NIH Intramural Sequencing Center (NISC).
… PR, Fargo DC, Mullikin JC, Wade PA. DNA methylation in mice is influenced by genetics as well as sex and life …
Clinical Research
The study collects genetic and medical information from people with GNE myopathy to understand the symptoms and clinical course of GNE myopathy.
… that supplementation of ManNAc to cell cultures or to mice with a dysfunctional GNE protein (as in GNE Myopathy) … Myopathy have shown a treatment effect of oral ManNAc in mice with GNE Myopathy . NIH researchers are participating … 2-epimerase/ N -acetylmannosamine kinase knock-in mice from severe neonatal glomerular hematuria and …