Search Results
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… Medicine that they have succeeded in coaxing cultured cells to exhibit the signature traits of the disease. Using … that has successfully corrected the malfunctioning cells. … accumulated glucocerebroside is the macrophage, a type of white blood cell. Macrophages are cellular housekeepers that …
Talking Glossary
Phenotypic variance is the observed variability of a particular trait. For many measurable traits (such as height, skin color, and blood pressure) phenotypic variation can be thought of as a distribution.
… many measurable traits (such as height, skin color, and blood pressure) phenotypic variation can be thought of as a … many measurable traits (such as height, skin color, and blood pressure) phenotypic variation can be thought of as a … many measurable traits (such as height, skin color, and blood pressure) phenotypic variation can be thought of as a …
Talking Glossary
Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell.
… (including humans), chromosomes reside in the nucleus of cells. Humans have 22 pairs of numbered chromosomes …
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… or plant. In animals, female gametes are called ova or egg cells, and male gametes are called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… when two genetic neighborhoods merge in brain tumor cells. Researchers found that one gene came under the control … IDH gene was mutated, particular portions of the cancer cells' DNA became studded with chemical tags called methyl … of these genetic neighborhoods, a gene called PDGFRA makes cells grow, or increase in number, but is rarely turned on. …
Educational Resources
Bacteria are small single-celled organisms.
… and in fact is estimated to contain more bacterial cells than human cells. Most bacteria in the body are harmless, and some are …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… settings, making genomic testing as routine as complete blood counts (CBCs). Speakers: Jennifer Posey, M.D., Ph.D., … and cellular dataset to help scientists understand how cells respond to specific biological and environmental … LINCS program generated dataset to help understand how cells functio …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… of DNA and other molecules that may be retained as cells divide to make more cells. … of DNA and other molecules that may be retained as cells divide to make more cells. When found in DNA, methylation can alter gene … of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of …
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… structures located inside the nucleus of animal and plant cells. … structures located inside the nucleus of animal and plant cells. Each chromosome is made of protein and a single … packaging, DNA molecules would be too long to fit inside cells. For example, if all of the DNA molecules in a single …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.