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Educational Resources
A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.
… A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest. … Chromosome, Gene, Deoxyribonucleic Acid (DNA), Positional Cloning … A physical map, as related to genomics, is a graphical representation of physical locations …
The Genomics Landscape
In the March 2020 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the newly appointed Dr. Chris Gunter's role as Senior Advisor for Genomics Engagement as well as the 30 oral histories to celebrate the 30th anniversary of the launch of the Human Genome Project.
… The first such AGBT meeting was held in 2000, when most of the attendees were – in one way or another – busily … it is gratifying to reflect on the amazing metamorphosis of genomics over the last two decades, especially with respect … Current : Jan. 17 – Apr. 12, 2020 Museum of Science & History Jacksonville, Florida …
Talking Glossary
Methylation is a chemical modification of DNA and other molecules that may be retained as cells divide to make more cells. regulating the production of proteins that the gene encodes.
… Methylation is a chemical modification of DNA and other molecules that may be retained as cells … Methylation is a chemical modification of DNA and other molecules that may be retained as cells … make more cells. When found in DNA, methylation can alter gene expression. In this process, chemical tags called methyl …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… decades, but the conversation about the science and ethics of genome editing has grown louder due to faster, cheaper, … While the popular media tends to focus on the potential use of genome editing in humans, the main application of this … will aid the development of new treatments, including gene therapy . …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… A transcriptome is a collection of all the gene readouts present in a cell. … The human genome is made up of DNA (deoxyribonucleic acid), a long, winding molecule that … words, copied - into RNA ( ribonucleic acid ) . These gene readouts are called transcripts, and a transcriptome is …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… A complex disease is caused by the interaction of multiple genes and environmental factors. … Genes, Cancer, Heart Disease, Gene-environment Interactions … disease (or condition), when discussed in the context of genetics, reflects a disorder that results from the …
Clinical Research
The CLINSEQ® Study seeks to learn about the role that your genes play in your health.
… by getting a DNA sample from you, sequencing most or all of your genes, and comparing that to what we know about your … health histories. We look at genes related to a variety of conditions, including heart disease, breast cancer, and … we still need more volunteers for the study. Each member of the study has a clinical visit and tests to look at heart …
News Release
NHGRI researchers have discovered clues to the possible cause of recurring, non-contagious fevers and sores that affect only children. Several genes have been implicated with the syndrome, known as PFAPA syndrome (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis), which could lead to new treatments.
… the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, have discovered clues … researchers have long thought that answers may lie in genomics. After ruling out the possibility that the syndrome is caused by mutations in a single gene, they considered the possibility that multiple genes are …
The Genomics Landscape
In the April 2019 edition of The Genomics Landscape, NHGRI Director Eric Green previews the redesigned genome.gov website and its new features.
… . Specifically, the story focused on the recent successes of one of NIH's intramural researchers, Dr. John Tisdale of the … Lung, and Blood Institute, who is working to develop a gene therapy-based treatment for sickle cell disease. This … and accomplishments from the institute and the field of genomics.  …
The Genomics Landscape
In the November 5, 2020 edition of The Genomics Landscape, Dr. Eric Green focuses on the 2020 Strategic Vision.
… for NHGRI. In addition to celebrating the 30th anniversary of the launch of the Human Genome Project (HGP), which was featured in last month’s The Genomics Landscape , the institute also published the 2020 … to provide a compelling and informative vision for human genomics in the coming decade. I would also like to draw your …