Search Results
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… and#collaboration#with# the#Genotype#Tissue#Expression# (GTEx)#project,#which#is#also# …
Research at NHGRI
The Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch studies the genomic and social determinants of complex diseases.
… genomic and social determinants; their effects on gene expression; as well as their contribution to health … cardiovascular disease morbidity and mortality and on gene expression among disproportionately affected subpopulations. …
News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… facilitates cell growth and division, and the increased expression of JAK2 may inappropriately activate cell growth. … PD-L2, which suppress immune responses; their increased expression may help tumors escape destruction by the immune … process of adding methyl groups to DNA, which reduces gene expression. Hypermethylation occurs when this mechanism …
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… Expression Analysis, Functional Enrichment, and Network …
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… PsychENCODE may help demonstrate how targeted epigenomic tissue profiling can aide functional element identification … thoroughly and systematically by the proposed initiative. Genotype Tissue Expression (GTEx) collects gene expression data for ~30 …
The Genomics Landscape
In the September 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, recaps the April 2023 virtual reunion of the leaders of the five genome-sequencing centers (G5), where they tell the untold story on how they ushered the Human Genome Project across the finish line in 2003.
… Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant …
Staff
Eric D. Green, M.D., Ph.D., served as the director of the National Human Genome Research Institute (NHGRI) at the U.S. National Institutes of Health (NIH) from 2009 to 2025.
… AP. A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet , 5:e1000436. … JB, Sawyer S, Lockhart NC, Demchok J, and Moore HF. The Genotype-Tissue Expression (GTEx) project. Nat Genet , 45:580-585. …
Educational Resources
Recessive Traits and Alleles is a quality found in the relationship between two versions of a gene.
… Gene, Genotype, Inherited, Mutation, Phenotype, Allele, Dominant …
Staff
Dr. Michael Erdos is an Associate Investigator in the Molecular Genetics Section of the Center for Precision Health Research.
… Network for Systematic Analysis of Pancreatic Islet RNA Expression (InsPIRE) consortium. In addition, he is a … of T2D. Dr. Erdos is the lead scientist in the FUSION tissue biopsy project which aims to investigate tissue … cell state and functional consequence are integrated with genotype and polygenic risk to investigate the functional …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… RNA molecules involved in the regulation of gene expression. When the AAV was inserted near Mir341 , the vector caused elevated expression of the gene, which the researchers believe … that vector did not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. …