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Event
On November 16-17, 2023, the National Human Genome Institute will co-sponsor a workshop, Advances in the Genetic Architecture of Complex Human Traits, to take a historically grounded and forward-looking approach towards dissecting the genetic architecture of complex traits in humans.
… Is the goal to capture more genetic variation, and thus biological variation, or more environmental variation, … our understanding of genetic architecture across levels of biological organization? Emerging data from cancer biology, … how it has shaped genetic architecture across levels of biological organization?  It is generally believed that less …
Explainer
Appropriate use of population descriptors in research is a critical scientific issue that is important for advancing genomic science and improving healthcare across human populations.
… that is not measured in research often hides underlying biological, environmental or social factors that may … race and ethnicity have been improperly treated as biological or innate characteristics. In society, there are … of potential contributing factors, including genomic, biological or clinical traits; components of the natural, …
Research Funding
A list of members who contribute to the goals of the IGVF Consortium by generating data and/or analyses, sharing data and/or analyses freely through the IGVF Data and Administrative Coordinating Center (DACC), and/or by contributing to cross- consortium integrative analyses.
… and cell types, (2) identify causal mediator genes and pathways underlying disease variation, and (3) decode … consortium group to identify causal variants, genes, and pathways associated with cardiometabolic disease.  Matthias … we are interested in building novel models and gaining biological insights from pooled or single-cell CRISPR screens …
The Genomics Landscape
In the March 2024 issue of The Genomics Landscape, NHGRI Director Eric Green spotlights the Centers of Excellence in Genomic Science (CEGS) Program evaluation.
… involve strengthening the connectivity of particular pathways in the brain. The researchers propose that either … new technologies and linking existing technologies to biological challenges have proven to be fundamental to the … and its focus on technology development with links to biological questions. Suggestions for improving the CEGS …
Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
… and quantitative genetics to identify the genes and gene-pathways that drive disease. Newly discovered genes are then … and using the resulting information to refine the genes, pathways, and environmental influences involved in disease …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… young patients and made progress in understanding the biological pathways and proteins that are important for the regulation of the immune system's responses." Cells use biological pathways to send and receive chemical cues in …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… variations and ranks them according to their clinical and biological relevance to a patient's cancer. …
News Release
Four NHGRI researchers share the steps toward a career in genomics with 60 Brooklyn-area high school students.
…  Diego Loayza, Ph.D. , assistant professor, Department of Biological Sciences, Hunter College, New York, N.Y., who …
Fact Sheet
A fact sheet detailing how the project began and how it shaped the future of research and technology.
… How did the Human Genome Project affect biological research in general? The Human Genome Project … was driven by a desire to explore an unknown part of the biological world — as opposed to first formulating a theory … How did the Human Genome Project foster ethics in biological research? …
Staff
Binta Jalloh is a postdoctoral fellow at the Center for Research on Genomics and Global Health (CRGGH).
… that are associated with cardiometabolic traits, and the pathways mediated by these miRNAs in cardiometabolic disease …