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The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… Last week, we started a new fiscal year for the federal government. As is often the case, we began … on last year’s budget — awaiting passage of a new budget for the current fiscal year. The CR allows NHGRI to continue … at the NIH funding process as well as provide tips and tools for successful grant writing; this session will take …
Staff
Dr. James Thomas is the acting director for the NIH Intramural Sequencing Center (NISC).
… Dr. James Thomas is the director of the NIH Intramural Sequencing Center. He oversees the importation and use of DNA sequencing technologies, protocols and analyses, ensuring … that NIH investigators have access to cutting-edge DNA sequencing methods and specialized genomics protocols to meet …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… The National Institutes of Health will fund a set of genome sequencing and analysis centers whose research will focus on … CMG researchers have also developed and disseminated tools that enable scientists to rapidly discover such genes. … find genes that cause Mendelian diseases, with a focus on novel genes, she said. NHGRI, pending available funds, will …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… want knocked out," said Dr. Sood. "It's a service provided for NHGRI investigators." Usually the genes are selected … paper-clip-sized siblings without a genetic mutation. For these researchers, the reasons for using zebrafish as … Charles Venditti, M.D., Ph.D., head of the Organic Acid Research Section, who works on a group of genetic …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
… isolating and copying a particular DNA segment of interest for further study. …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), … to the cell cytoplasm (watery interior), where it is used for synthesizing the encoded protein. …
News Release
Researchers from NHGRI, Oxford University and other National Institutes of Health centers have developed and tested a new method to predict hospital-acquired infections involving five other important pathogens.
… "But is there a way we can accurately predict your risk for acquiring a hospital-acquired infection just by using … hospital data?" Hospital staff usually test patients for infections when they start showing symptoms, but that … Health Service (NHS) hospitals in Oxfordshire, U.K. for at least 48 hours between 2011 and 2015. The NHS, which …
Educational Resources
Transgenic means that one or more DNA sequences from another species have been introduced by artificial means.
… Cell, Cloning, Deoxyribonucleic Acid (DNA), Gene, Germ Line … Transgenic organisms are generated in the laboratory for research purposes. …
Educational Resources
A primer is a short, single-stranded DNA sequence used in the polymerase chain reaction (PCR) technique.
… Deoxyribonucleic Acid (DNA), Gene Amplification, Hybridization, Polymerase … in a very short timeframe. Primers are also used in DNA sequencing and other experimental processes. …
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will annotate de-identified research exome/genome data for the presence of possible actionable secondary variants. … NHGRI to Intramural Investigators employing exome/genome sequencing. ​ …