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News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare … designed gene therapies using an adeno-associated virus (AAV) as a vector to deliver the corrected gene to a specific … but do not cause disease. A vector is a DNA molecule of AAV used as a vehicle to carry corrected genetic material …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… Dr. Chandler’s research focused on adeno-associated virus (AAV) gene therapy for the treatment of hemophilia A, a genetically … of clinical trial start-ups by using the same gene delivery system and manufacturing methods for multiple rare …
Educational Resources
Gene regulation is the process of turning genes on and off.
Gene Regulation … Gene regulation is the process of turning genes on and off. … Gene Expression, Genes, DNA, Transcription Factors … Gene regulation is the process used to control the timing, …
Educational Resources
The gene is the basic physical unit of inheritance.
Gene … The gene is the basic physical unit of inheritance. … Inheritance, Gene, Double Helix, DNA, DNA Sequence … The gene is considered the basic unit of inheritance. Genes are …
Educational Resources
A candidate gene is a gene whose chromosomal location is associated with a particular disease or other phenotype.
… Candidate Gene … A candidate gene is a gene whose chromosomal location is associated with a … Traits, Disease, Linkage Analysis … The term candidate gene refers to a gene that is believed to be related to a …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
… and investigate the health consequences of their genes and gene variants. … Reversing a Long-Standing Paradigm To … them to recall genotyped people and examine the genes and gene variants' influence on their phenotypes, an individual's … traits or symptoms and then searching for genes or gene variants that cause or contribute to them. NIH will …
Educational Resources
Gene environment interaction is an influence on the expression of a trait that results from the interplay between genes and the environment.
Gene Environment Interaction … Gene environment interaction is an influence on the … … Genes, Environmental Factors, Genetics, DNA … Gene–environment interaction refers to the interplay of genes … ultraviolet radiation from the sun and social context. … Gene environment interaction is an influence on the …
Educational Resources
A gene pool is the total genetic diversity found within a population or a species.
Gene Pool … A gene pool is the total genetic diversity found within a … Diversity, Genes, Extinction, Population Genetics … A gene pool refers to the combination of all the genes … present in a reproducing population or species. A large gene pool has extensive genomic diversity and is better able …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… of Cardiovascular Disease in Africans Americans Study (GENE-FORECAST®) study is developing a community-based cohort … ancestry-related genomic variation in African-Americans. … GENE-FORECAST® will test the working hypothesis that … of these putative functional DNA variants of interest. GENE-FORECAST® Study Flyer … You will be able to participate …
Educational Resources
Gene mapping is the process of establishing the locations of genes on the chromosomes.
Gene Mapping … Gene mapping is the process of establishing the locations of … Analysis, Genome Sequencing, DNA Sequencing, Chromosomes … Gene mapping refers to the process of determining the … on chromosomes. Today, the most efficient approach for gene mapping involves sequencing a genome and then using …