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Educational Resources
A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
… mutation … a mutation is a change in a dna sequence. mutations can result from dna copying mistakes made during cell division, exposure to …
Educational Resources
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.
… amino acid in the resulting protein. … missense mutation , dna mutation , dna sequence … a missense mutation is when the change of a …
Educational Resources
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.
… not divisible by three. … genetic mutation , base pairs, dna sequence … a frameshift mutation is a type of mutation … if a mutation disrupts this reading frame, then the entire dna sequence following the mutation will be read incorrectly. …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… researchers and their collaborators have identified mutations in the taf1 gene. they've also demonstrated that … darryl leja, nhgri.   dr. bell and her team isolated dna from tumor cells and from normal cells from patients with … in the protein-coding regions of the tumor and normal dna from 16 ccec patients, and found mutations in 222 genes …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… the dna microarray is a tool used to determine whether the dna from a particular individual contains a mutation in … it can be very difficult to develop a test to detect these mutations , because most large genes have many regions where …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… that these cells are prone to increased numbers of genetic mutations . a new study by scientists at the national human … of health, suggests that ipscs do not develop more mutations than cells that are duplicated by subcloning. … and the subcloning techniques. they then sequenced the dna of the skin cells as well as the ipscs and the subcloned …
News Release
Researchers sequence the genomes of healthy participants, then analyze the data to find presumed, mutations that might lead to a genetic condition.
… then analyzed the data to find "putative," or presumed, mutations that would almost certainly lead to a genetic … they have only recently been able to address it as dna sequencing costs have plummeted. at this rate, just above … of how these mutations affect health. "we want to add dna sequencing to the physician's toolbox," dr. biesecker …
Educational Resources
Deletion is a type of mutation involving the loss of genetic material.
… loss of genetic material. … genetic mutation , base pair, dna , chromosome … deletion is a type of mutation involving … material. it can be small, involving a single missing dna base pair, or large, involving a piece of a chromosome. … …
Outreach
A list of high quality educational activities to engage students on DNA Day.
dna  day essay contest from ashg american society of human genetics (ashg) dna day essay contest is open to students in grades 9-12 … wednesday, march 3, 2021 and winners will be announced on dna day ( friday, april 23, 2021 ). hhmi biointeractive: …
Educational Resources
A mutagen is a chemical or physical phenomenon, such as ionizing radiation, that promotes errors in DNA replication.
… such as ionizing radiation, that promotes errors in dna replication. … mutagen, dna mutation , dna replication, cancer … a mutagen is a … in dna replication. exposure to a mutagen can produce dna mutations that cause or contribute to diseases such as …