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Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
animal model … an animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans. … biomedical research, ethics, … it can mimic aspects of a disease found in humans. animal models are used to obtain information about a disease and its …
Staff
Dr. Raman Sood is the director of the Zebrafish Core at the National Human Genome Research Institute. ​
… in toronto, canada. she has been at national institutes of health since 1994, first at national institute of … positional cloning to functional genomics analysis using animal models . she has participated in several collaborative …
Staff
Dr. Shawn Burgess is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
… ph.d. in genetics from the johns hopkins university school of medicine, where he studied the genetics of mitochondrial … deafness will also be targeted, in order to create new animal models relevant to one of the most common health problems in …
News Release
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… the researchers used type 2 diabetes mellitus (t2d) as the disease model for their study. an estimated 30 million people in the us suffer from the condition, making it one of the most common and costly chronic diseases to treat. t2d … history information are piecemeal and specific, relying on models that can only be used for complex diseases such as …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… doctors, the deadliest enemy is metastasis - the migration of cancer cells from the original tumor to other places in … they have developed transgenic zebrafish as a live animal model of metastasis - offering cancer researchers a … institute (nhgri), and their colleagues wrote in disease models & mechanisms, published online on march 25, 2015. …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… by replacing it or disrupting it with an artificial piece of dna. … knocking out the activity of a gene provides … therapies can be developed and tested. many of these mouse models are named after the gene that has been inactivated. … means now available for studying gene function in a living animal. such studies will accelerate efforts to translate …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… prabarna ganguly, ph.d. … nhgri-supported research of  hydractinia  could provide clues to human reproductive … like an unlikely study subject for researchers, but this animal has a rare ability ­– it can make eggs and sperm for … a surprisingly large number of genes that are like human disease genes, making it a useful animal model for studying …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… the hd gene on chromosome 4. the gene codes for production of a protein called "huntingtin," whose function is still … using pet scanning and other imaging technologies. animal models : scientists hope to learn more about the symptoms and …
The Genomics Landscape
In the November 2019 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the International Common Disease Alliance's scientific plenary and launch meeting in September, which included an international panel on opportunities emerging outside the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, data sharing, and ethics.
… to develop a graphical display illustrating the scale of human genome sequence. the wall is now enhanced with a … linked to diabetes through a dna-regulating gene in animal models one little girl’s story highlights the promise of
News Release
NIH researchers demonstrated that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1.
… jeannine mjoseth … for the first time, national institutes of health (nih) researchers have demonstrated in mice that … correcting the single faulty gene that causes niemann-pick disease , type c1 (npc1). the gene therapy involved inserting a functional copy of the npc1 gene into mice with the disease ; the treated …