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Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
stem cell … a stem cell is a cell with the potential to form … of the different cell types found in the body. when stem cells divide, they can form more stem cells or other cells that perform specialized functions. embryonic stem cells have the potential to form a complete …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. investigators from two national human … the genome what to do - among three types of cells : mouse embryonic stem (es) cells , embryonic fibroblasts and hematopoietic …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… of 8,500 knockouts of mouse genes, in the form of embryonic stem (es) cells . he is now working to implement the knockout mouse …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… into adult mice. the lack of adult mice limits studies to embryonic development and often makes it more difficult to … disease.   … researchers begin by harvesting embryonic stem (es) cells from early-stage mouse embryos four days after …
Staff
Dr. Paul Liu is NHGRI's deputy scientific director and a senior investigator in NHGRI's Translational and Functional Genomics Branch. ​
… during leukemia development by microarray analysis with cells from cbfb-myh11 knock-in mice, and identified … mouse models. the zebrafish is a useful model for studying embryonic development and is easily amenable to large-scale … made novel findings regarding its role in hematopoietic stem cell production (bresciani, blood in press). overall the …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… called hydractinia, does so because it produces germ cells , which are precursors to eggs and sperm, nonstop … reported that activation of the gene tfap2 in adult stem cells in hydractinia can turn those cells into germ … similar to gonads in species like humans. during human embryonic development, a small pool of germ cells that will …
Staff
Dr. Pamela Schwartzberg is a senior investigator in NHGRI's Genetic Disease Research Branch.
… antigen receptors: surface immunoglobulins (ig) on b cells, and t cell receptors (tcr) on t cells. together with … in c-abl introduced by homologous recombination in murine embryonic stem cells . science , 246:799-803. 1989. [ pubmed ] debnath …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… neural progenitor differentiation to neurons during embryonic development, leading to the zebrafish mind bomb … in vitro hematopoietic differentiation of mouse embryonic stem cells and this role of menin is mediated by its ability to …
Fact Sheets
Cloning describes a number of different processes that can be used to produce genetically identical copies of a biological entity.
… a wide range of biological materials, including genes, cells , tissues and even entire organisms, such as a sheep. … … copies of whole animals. therapeutic cloning produces embryonic stem cells for experiments aimed at creating tissues to …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… for making proteins, which direct the activities of cells and functions of the body. examples of genetic or … (see: frequently asked questions about pharmacogenomics ). stem cell therapy stem cells have two important … their unspecialized state and make copies of themselves. embryonic stem cells come from the embryo at a very early …