Factor V Leiden thrombophilia is an inherited disorder of blood clotting.
… related to blood clotting, and circumstantial risk factors, such as surgery, use of oral contraceptives and … had only one DVT or PE, unless there are additional risk factors present. Having had a DVT or PE in the past increases … are counseled about reducing or eliminating other factors that may add to one?s risk of developing a clot in …
Epigenetics is an emerging field of science that studies heritable changes caused by the activation and deactivation of genes without any change in the underlying DNA sequence of the organism.
… the degrees to which genes are turned on and off. Certain epigenetic modifications may be passed on from parent cell to … or from one generation to the next. The collection of all epigenetic changes in a genome is called an epigenome. … …
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
Environmental factors, as related to genetics, refers to exposures to substances (such as pesticides or industrial waste) where we live or work, behaviors (such as smoking or poor diet) that can increase an individual’s risk of disease or stressful situations (such as racism).
… Environmental Factors … Environmental factors, as related to genetics, refers to exposures to … or stressful situations (such as racism). … Environmental factors, as related to genetics, refers to exposures to …
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… Prabarna Ganguly, Ph.D. … Comparing epigenetic differences between humans and domestic dogs … to study the aging process. By comparing when and what epigenetic changes mark certain developmental periods in … involves epigenetics -- gene expression changes caused by factors other than the DNA sequence itself. Recent findings …
Lindsey Criswell, who became the director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases in February, 2021 is also an associate investigator in NHGRI's Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… Disease Genomics Branch. … Lindsey Criswell, genetic risk factors, autoimmune disease, rheumatoid arthritis (RA); … complex (MHC), biological pathways, genetic ancestry, epigenetic factors … Lindsey Criswell, who became the director of the …
Research at NHGRI
The Translational and Functional Genomics Branch explores the genetic, epigenetic and metagenomic basis of human disorders.
… function contribute to health by exploring the genetic, epigenetic and metagenomic basis of human disorders. … TFGB … and Functional Genomics Branch explores the genetic, epigenetic and metagenomic basis of human disorders. … The … and Functional Genomics Branch explores the genetic, epigenetic and metagenomic basis of human disorders. … …
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… Section's research objectives is to understand the epigenetic changes that accompany red cell differentiation, including how the erythroid epigenetic profiles differ from the profiles in cells from … epigenetic marks and sites occupied by transcription factors, primarily focusing on cell lines or cultured cells. …
A complex disease is caused by the interaction of multiple genes and environmental factors.
… by the interaction of multiple genes and environmental factors. … Genes, Cancer, Heart Disease, Gene-environment … by the interaction of multiple genes and environmental factors. … Educational Resources …
Receiving a cancer diagnosis can feel like losing control of everything.
… One of these roads involves how the cell reads the epigenetic code, the "other genetic code" that sits atop a … chemical groups - like flags on the DNA - that make up the epigenetic code and act as guideposts. These flags help the … of cancer and the location, but also the molecular and epigenetic signatures of the patient's specific cancer. With …