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Jobs at NHGRI
NHGRI is seeking a postdocs in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch in Bethesda, Maryland.
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… zebrafish could dramatically accelerate the discovery of gene function and the identification of disease genes in humans, … of genome research , the researchers reported that the gene -editing technology known as crispr/cas9 is six times …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… is understanding how genomic variation affects genome function to influence phenotypes. in 2019, the national human … 5, 2020   rfa-hg-20-044 :  defining genomic influence on gene network regulation (u01 clinical trial not allowed) … :   single-cell profiling of regulatory element and gene activity in relationship to genome function (um1 …
Educational Resources
Gene regulation is the process of turning genes on and off.
gene regulation … gene regulation is the process of turning genes on and off. … gene expression, genes , dna, transcription factors … gene regulation is the process of turning genes on and off. …
News Release
Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.
… plays in modulating that expression. … an atlas of human gene expression the gtex awards will contribute to a resource … inherited spelling changes in the dna code - may influence gene activity and lead to disease. the grants will add data … current gtex project in assessing genomic variation and gene expression," explained simona volpi, pharm.d., ph.d., …
The Genomics Landscape
In the September 3, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about the Impact of Genomic Variation on Function (IGVF) Consortium, the 2020 Genomic Innovator Awards and more.
… is understanding how genomic variation affects genome function to influence phenotypes. nhgri recently issued … and assaying for specific phenotypes; measuring changes in gene and regulatory element activity; identifying and testing … function and phenotype , defining genomic influence on gene network regulation , single-cell profiling of regulatory …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… in the rfa, individual projects collect genomic data on gene expression, as well as surrogate markers of regulatory … in different cell fates or cell states. they use the gene expression and functional element data to construct gene regulatory network models, taking advantage of the …
Event
NHGRI workshop seeking scientific perspectives for relating genomic variation to human phenotype.
… 11:05 - 11:25 a.m. nhgri's current approach to "variant to function to disease" nhgri staff 11:25 - 12:10 p.m. current … of the regulatory consequences of variants, and modeling gene regulation co-chairs: trey ideker christina leslie 12:30 … of genome variation, including beyond single variant/ gene panel: nadav ahituv dana crawford neville sanjana …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… of cardiovascular disease in africans americans study ( gene -forecast®) study is developing a community-based cohort … ancestry-related genomic variation in african-americans. … gene -forecast® will test the working hypothesis that … pressure), laboratory tests (e.g. lipid levels, kidney function ), social determinants profiles (e.g. socioeconomic …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute. ​
… interplay of silencing elements in regulating active gene expression, dr. elnitski developed a system to detect … promoters are now widely accepted as a mechanism of gene regulation. however in 2007, the basic set of genes with … genes , was unknown. dr. elnitski's group elucidated this gene collection in several peer-reviewed publications …