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Staff
Lisa Garrett is a staff scientist and director of the NHGRI Transgenic Mouse Core.
… at nci, frederick, maryland. generating transgenic mice for models of cancer. at this time, she started her … core website along with other useful information for using genetically engineered mice in research. most recently, ms. garrett …
Educational Resources
A knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes.
… … a knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes. … knockout … more specific genes. scientists create knockouts (often in mice ) so that they can study the impact of the missing genes …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… of different model organisms are used in this regard, but mice are especially useful because they share mammalian …
News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… genetic disease research branch. "if we knock it out in mice , we don't get the t follicular helper cells, or very … and maintaining tfh cells. when the researchers bred genetically engineered mice suppressing the gene that codes for tcf1, the …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing ​
… in basic research. editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly … and reduce off-target edits. the structures of zfns are engineered from naturally-occurring  proteins  that were … successful zinc finger proteins, and a new zfn must be engineered for each new target dna sequence. transcription …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… used a dna-editing technique to extend the lifespan of mice with the genetic variation associated with progeria,  a … this mutation might affect progeria-like symptoms in mice . "the toll of this devastating illness on affected … injection of the dna-editing mix into nearly a dozen mice with the progeria-causing mutation soon after birth. the …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… of times more quickly than mammalian models such as mice (although not nearly so fast as flies). it can be made … to test their zebrafish screen, the researchers exposed genetically engineered embryos, in which the pllp cells glowed brightly …
File
… for social and political misuse. In addition, the use of genetically modified plants will necessitate the development … to inactivate or Òknock-outÓ any partic- ular gene in mice bred for this purpose, and this is proving an extremely … diseases. Genetically modified (GM) animals are being engineered to produce in their milk or tissues therapeutic …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… transgenic mouse core uses crispr to generate laboratory mice with specific gene alterations for the study of human … that nhgri helped develop. it was designed to generate mice containing mutations in every gene of the mouse genome. … for komp2, researchers are using crispr to create these mice more efficiently. any researcher can purchase these mice
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… by the pathogen. to test this hypothesis, the researchers genetically engineered mice with fmf-causing genomic variants. they infected both …