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Staff
Dr. Douglas Stewart is an adjunct investigator in NHGRI's Genetic Disease Research Branch.
… disorder. dr. stewart is leading a project which uses new high-throughput sequencing technologies to identify, catalog and characterize …
Staff
Dr. James Thomas is the deputy director for the NIH Intramural Sequencing Center (NISC).
… medicine before returning to nhgri and the nih intramural sequencing center in 2011. he is currently the deputy … … james thomas, nih intramural sequencing center (nisc), high-throughput sequencing , comparative genomics, data production …
News Release
Micro-sized technologies are among the approaches researchers will use to develop high quality, low cost DNA sequencing technology.
… - are among the approaches researchers will use to develop high quality, low cost dna sequencing technology through new grants from the national … methods with biological nanopores to enable high-throughput sequencing . the latter refers to a very high rate …
Research at NHGRI
The NIH Intramural Sequencing Center is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence.
… the nih intramural sequencing center (nisc) , established in 1997, is a … institutes of health (nih) access to well established, high-throughput dna sequencing , nisc works closely with nih …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… and the field of genomics.   … the  nih intramural sequencing center  (nisc) sits on the top floor of a research … unassuming location houses the center's state-of-the-art, high-throughput dna sequencing facility. in a rather modest start …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing ​
… grown louder due to faster, cheaper, and more efficient technologies . … while the popular media tends to focus on … recombination is that it is inaccurate and has a high rate of error when the injected dna fragments insert … xu, l. s., gallardo, v., . . . burgess, s. m. (2015). high-throughput gene targeting and phenotyping in zebrafish using …
Staff
Abdel Elkahloun is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… patel n, elkahloun a, lee mj, trepel j, ferrer m, pacak k. high-throughput screening for the identification of new … ds, elkahloun ag, singh ln, lee-lin sq; nisc comparative sequencing program, kolodgie fd, cheng q, zhao x, chen my, …
Staff
Dr. Mullikin is director of the NIH Intramural Sequencing Center (NISC).
… to analyze large data sets generated by systematic dna sequencing projects. a highly skilled computational … are in developing novel and efficient algorithms using high-performance compute clusters to reduce large data sets … change, which has now seen next-generation sequencing throughput increase 20-fold. this growth has complemented …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… genome was announced by the international human genome sequencing consortium ( finishing the euchromatic sequence of … development phase of the project aimed to develop new high throughput methods to identify functional elements. the goal …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… on an organism lacking it. such larger scale - termed high-throughput - gene targeting in an animal model could be … of a specific dna sequence ) and high-throughput dna sequencing , the researchers determined that overall, …