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News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… for clues about how the body signals the lack of oxygen in melanoma skin cancer, National Institutes of Health (NIH) … that were associated with the amount of time it took the melanoma to move from the original tumor to the rest of the … their findings February 6, 2017, in Pigment Cell and Melanoma Research . "These newly identified genes and genetic …
Genetic Disorders
Skin cancer is the most common type of cancer in the United States.
… United States. The most virulent form of skin cancer is melanoma. In some parts of the world, especially in Western countries, the number of people who develop melanoma is increasing faster than any other cancer. In the United States, for example, the number of new cases of melanoma has more than doubled in the past 20 years. … Three …
Staff
Dr. Paul Meltzer is an adjunct investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… molecular profiling technologies, osteosarcoma profiling, melanoma profiling, breast cancer profiling, technology … molecular profiling technologies, osteosarcoma profiling, melanoma profiling, breast cancer profiling, technology …
File
… 20,000 Lung Cancer 20,000 Rheumatoid Arthritis 30,000 Melanoma 13,000 Lupus 15,000 GWAS samples in 18 diseases: …
File
… reveal a molecular profile associated with poor melanoma prognosis Document 38 Genetic structure of the …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… is associated with Waardenburg Syndrome IV and with human melanoma, and also identified the lysosomal transmembrane … somatic mutations of SOX10  are rarely present in human melanoma, the most lethal form of skin cancer in the United … They went on to demonstrate that reduction of SOX10 causes melanoma cells to undergo cellular growth arrest and …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute. ​
… of a recurrent synonymous driver mutation identified in melanoma (published in PNAS ). One of the most intriguing … identifies a recurrent functional synonymous mutation in melanoma. Proc Natl Acad Sci , 110:13481-6. 2013. [ PUbMed ] … functional relevance of somatic synonymous mutations in melanoma and other cancers. Pigment Cell Melanoma Res , doi: …
Staff
Dr. Bettie Graham provides leadership for all of NHGRI's extramural training programs.
… 887, 1978. [ PubMed ] Graham, B.J. and Duane, T.D.: Ocular Melanoma Task Force Meeting. Am J. Ophtha , 90 (5): 728 733, …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… of the prostate, endometrium, lung, bladder, and breast; melanoma, and Fanconi anemia. These research efforts are …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… from some types of advanced cancers, namely myeloma, melanoma and sarcoma. It would be one of the first studies in …