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Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… is principally responsible for supervising the knockout mouse project (komp). the goal of the komp program, expected … late in 2011, is the production of 8,500 knockouts of mouse genes , in the form of embryonic stem (es) cells. he is now …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… a knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked … about what that gene normally does. humans share many genes with mice. consequently, observing the characteristics …
Educational Resources
A knockout typically refers to an organism that has been genetically engineered to lack one or more specific genes.
… been genetically engineered to lack one or more specific genes . … knockout mouse , genetic engineering, gene , laboratory experiment … a … been genetically engineered to lack one or more specific genes . scientists create knockouts (often in mice) so that …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… new insights into the organization and regulation of our genes and genome … the encyclopedia of dna elements (encode) … millions of candidate dna “switches” from the human and mouse genomes that appear to regulate when and where genes … tag. animation depicting dna “switches” from the human and mouse genomes that appear to regulate when and where genes
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress … so different from those in people. building on years of mouse and gene regulation studies, they have developed a … in the human and mouse genomes. such elements include genes that provide instructions to build proteins, …
Staff
Lisa Garrett is a staff scientist and director of the NHGRI Transgenic Mouse Core.
… is a staff scientist and director of the nhgri transgenic mouse core at the nih. in 1984, she received her m.s. at … 1994 and completed her thesis, the tissue - specificity of mouse ets-1 regulatory region in a transgenic model. in 1994, … is sufficient and necessary for synovial joint formation. genes dev, 18(19):2404-17. 2004. [ pubmed ] crabtree, j.s., …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… controlling movement. midbrain neurons from the new mouse model. the green shows the clumped alpha-synuclein. … in the study, the authors used a parkinson's disease mouse model that carried extra copies of a mutated form of … is different about the cross-bred mice. ultimately, this mouse model can be used to develop and evaluate new …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… data to understand what elements are controlling what genes, in what cell types. the ability to make accurate … post-transcriptional response to pathogens, primary mouse macrophages christina leslie, ph.d. and alexander … populations in inflammation in vivo inflammation model, mouse t helper cells jeremy luban, m.d. and manuel garber, …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… mix of genetics and lifestyle. while changes in many genes themselves play a role, small variations in dna … other tissue. they found that more than 80 percent of the mouse genes had variations in the nearby regulatory dna that … of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic balance. nature …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… reading … dna-editing method shows promise to treat mouse model of progeria … using a recently developed dna …