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Research Funding
The Knockout Mouse Phenotyping Program (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… K The Jackson Laboratory The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) OD023222 … Jason D Baylor College of Medicine The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2) HG006348 … comprised of knockout information for all protein-coding genes in the mouse genome. … Humans share most of their genes
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress … so different from those in people. Building on years of mouse and gene regulation studies, they have developed a … in the human and mouse genomes. Such elements include genes that provide instructions to build proteins, …
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… new insights into the organization and regulation of our genes and genome … The Encyclopedia of DNA Elements (ENCODE) … millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes … tag. Animation depicting DNA “switches” from the human and mouse genomes that appear to regulate when and where genes
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
Mouse Model … A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, Laboratory …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked … about what that gene normally does. Humans share many genes with mice. Consequently, observing the characteristics …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… is principally responsible for supervising The Knockout Mouse Project (KOMP). The goal of the KOMP program, expected … late in 2011, is the production of 8,500 knockouts of mouse genes, in the form of embryonic stem (ES) cells. He is now …
Educational Resources
Gene regulation is the process of turning genes on and off.
… Gene Regulation … Gene regulation is the process of turning genes on and off. … Gene Expression, Genes, DNA, Transcription Factors … Gene regulation is the … used to control the timing, location and amount in which genes are expressed. The process can be complicated and is …
Educational Resources
The gene is the basic physical unit of inheritance.
… … The gene is considered the basic unit of inheritance. Genes are passed from parents to offspring and contain the … needed to specify physical and biological traits. Most genes code for specific proteins, or segments of proteins, … the body. Humans have approximately 20,000 protein-coding genes.   … The gene is the basic physical unit of …
Educational Resources
A candidate gene is a gene whose chromosomal location is associated with a particular disease or other phenotype.
… associated with a particular disease or other phenotype. … Genes, Chromosome, Phenotype, Traits, Disease, Linkage …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… mix of genetics and lifestyle. While changes in many genes themselves play a role, small variations in DNA … other tissue. They found that more than 80 percent of the mouse genes had variations in the nearby regulatory DNA that … of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic balance. Nature …