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Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… K The Jackson Laboratory The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) OD023222 … Jason D Baylor College of Medicine The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2) HG006348 … comprised of knockout information for all protein-coding genes in the mouse genome. … Humans share most of their genes
News Release
The Encyclopedia of DNA Elements (ENCODE) Project has created a detailed resource on the letters of life, DNA, identifying genes and regions that may regulate genes in the human and mouse genomes.
… new insights into the organization and regulation of our genes and genome … The Encyclopedia of DNA Elements (ENCODE) … millions of candidate DNA “switches” from the human and mouse genomes that appear to regulate when and where genes … tag. Animation depicting DNA “switches” from the human and mouse genomes that appear to regulate when and where genes
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress … so different from those in people. Building on years of mouse and gene regulation studies, they have developed a … in the human and mouse genomes. Such elements include genes that provide instructions to build proteins, …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
Mouse Model … A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, Laboratory …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked … about what that gene normally does. Humans share many genes with mice. Consequently, observing the characteristics …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… is principally responsible for supervising The Knockout Mouse Project (KOMP). The goal of the KOMP program, expected … late in 2011, is the production of 8,500 knockouts of mouse genes, in the form of embryonic stem (ES) cells. He is now …
Educational Resources
Gene regulation is the process of turning genes on and off.
… Gene Regulation … Gene regulation is the process of turning genes on and off. … Gene Expression, Genes, DNA, Transcription Factors … Gene regulation is the … used to control the timing, location and amount in which genes are expressed. The process can be complicated and is …
Educational Resources
The gene is the basic physical unit of inheritance.
… … The gene is considered the basic unit of inheritance. Genes are passed from parents to offspring and contain the … needed to specify physical and biological traits. Most genes code for specific proteins, or segments of proteins, … the body. Humans have approximately 20,000 protein-coding genes.   … The gene is the basic physical unit of …
Educational Resources
A candidate gene is a gene whose chromosomal location is associated with a particular disease or other phenotype.
… associated with a particular disease or other phenotype. … Genes, Chromosome, Phenotype, Traits, Disease, Linkage …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… mix of genetics and lifestyle. While changes in many genes themselves play a role, small variations in DNA … other tissue. They found that more than 80 percent of the mouse genes had variations in the nearby regulatory DNA that … of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic balance. Nature …