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Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… of a biological process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are … understand human physiology and disease. By using animal models, researchers can perform experiments that would be …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… from many of the same diseases. A large number of mouse models have been created to target specific human diseases …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… Scientists often use different strains of mice as animal models to study human diseases because most genes in humans … Dr. Bianchi’s group then compared the two mouse models and found that the extra 45 genes in the previous … historian. “As cognitive treatments based on genetic models become more feasible in the future, researchers, in …
News Release
Researchers build a statistical model using family health history to improve disease risk assessment
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… history information are piecemeal and specific, relying on models that can only be used for complex diseases such as … have a meaningful discussion on how we can integrate these models into real-life clinical settings.” In the near future, …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… mutations. … Gaucher disease, Parkinson's disease, mouse models, GBA1, alpha-synuclein, Ellen Sidransky, M.D., Nahid …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… C1. His preclinical proof-of-principal studies using MMA murine models have helped enable two clinical trials: one uses mRNA … research relating to the in vivo gene editing in murine models of MMA has shown that the corrected MMA …
News Release
UDN expands the footprint of the network with a new metabolomics core and increased model organism capabilities.
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data.
… element data to construct gene regulatory network models, taking advantage of the dynamics of the system as the … to another. They derive and test predictions from the models, to determine the accuracy of the models and to learn how to improve the models. Five awards …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Institute (NHGRI), and their colleagues wrote in Disease Models & Mechanisms, published online on March 25, 2015. … of the whole animal," he said. Coauthors of the Disease Models & Mechanisms paper, in addition to Drs. Burgess and … As a vertebrate, it is much closer to humans than research models like fruit flies and roundworms. It reproduces …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.