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Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… Sickle cell disease is a group of inherited red blood cell disorders. … Sickle cell disease is the most common inherited blood … about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle …
News Release
NHGRI researchers seek help from people with Sickle Cell Disease to find the factors - environmental, social and genetic - that impact the severity of symptoms.
… Jeannine Mjoseth … People with sickle cell disease (SCD) can experience excruciating pain all over … gene from a parent, the person is said to have sickle cell trait (SCT). People with SCT usually do not have any of the …
News Release
Researchers have now identified three health conditions for which people with SCT are at increased risk.
… 2.5 to 3 million people have a gene variant associated sickle cell trait (SCT) and most never have related health …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… debate about the multi-centric or unicentric origin of the sickle allele in favor of the latter, with an estimate that … a new set of 27 genetic variants inherited with the sickle allele that may influence disease severity. 4. We … of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project utilizes a deliberative stakeholder-engagement approach to develop patient educational materials for sickle cell disease gene therapy.
… It is imperative that patients with sickle cell disease who are considering gene therapy fully … Education Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS) study is … Health Information About Sickle Cell Disease Sickle Cell Trait National Human Genome Research Institute - Learning …
Fact Sheet
Today, gene therapy for sickle cell disease is considered experimental and only available to you if you participate in a clinical trial.
… a trial may be dependent on: Your age. Your diagnosis of sickle cell disease. Your response to other treatments. Whether you … appointments and bloodwork. …  … Today, gene therapy for sickle cell disease is considered experimental and only …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… navigate emerging developments in gene therapies for sickle cell disease. … New educational materials to help the sickle cell disease community learn about gene therapies for …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease (SCD). … A First-of-its-Kind Study CRISPR-Cas9 … Heart, Lung, and Blood Institute launched the Cure Sickle Cell Initiative  to accelerate development of the most …
Educational Resources
A trait is a specific characteristic of an organism.
… Trait … A trait is a specific characteristic of an organism. … Gene, Gene Expression, Phenotype, Genotype … A trait, as related to genetics, is a specific characteristic … quantitative (such as height or blood pressure). A given trait is part of an individual’s overall phenotype. … A trait …