Search Results

1 - 10 of 809
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
Sickle cell disease is a group of inherited red blood cell disorders. … Sickle cell disease is the most common inherited blood … about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle
News Release
NHGRI researchers seek help from people with Sickle Cell Disease to find the factors - environmental, social and genetic - that impact the severity of symptoms.
… Jeannine Mjoseth … People with sickle cell disease (SCD) can experience excruciating pain all over … gene from a parent, the person is said to have sickle cell trait (SCT). People with SCT usually do not have any of the …
News Release
Researchers have now identified three health conditions for which people with SCT are at increased risk.
… 2.5 to 3 million people have a gene variant associated sickle cell trait (SCT) and most never have related health …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… debate about the multi-centric or unicentric origin of the sickle allele in favor of the latter, with an estimate that … a new set of 27 genetic variants inherited with the sickle allele that may influence disease severity. 4. We … of the sickle allele will help clinicians redefine sickle cell subgroups and treat patients more effectively. This …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project utilizes a deliberative stakeholder-engagement approach to develop patient educational materials for sickle cell disease gene therapy.
… It is imperative that patients with sickle cell disease who are considering gene therapy fully … Education Project welcomes your feedback about the sickle cell disease gene therapy resources. Please email your …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS) study is … Health Information About Sickle Cell Disease Sickle Cell Trait National Human Genome Research Institute - Learning …
Fact Sheet
Today, gene therapy for sickle cell disease is considered experimental and only available to you if you participate in a clinical trial.
… a trial may be dependent on: Your age. Your diagnosis of sickle cell disease. Your response to other treatments. Whether you … appointments and bloodwork. …   … Today, gene therapy for sickle cell disease is considered experimental and only …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… navigate emerging developments in gene therapies for sickle cell disease. … New educational materials to help the sickle cell disease community learn about gene therapies for …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease (SCD).  … A First-of-its-Kind Study CRISPR-Cas9 … Heart, Lung, and Blood Institute launched the  Cure Sickle Cell Initiative  to accelerate development of the most …
Educational Resources
A trait is a specific characteristic of an organism.
Trait … A trait is a specific characteristic of an organism. … Gene, Gene Expression, Phenotype, Genotype … A trait, as related to genetics, is a specific characteristic … quantitative (such as height or blood pressure). A given trait is part of an individual’s overall phenotype. … A trait