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Staff
Stacie Anderson is the director of the Flow Cytometry Core at the National Human Genome Research Institute. ​
… involving flow cytometry, permitting high quality single cell analyses to be performed by nhgri investigators. these …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… cellular signatures (lincs). discovering such cell responses will improve scientists' understanding of cell … molecular and biochemical responses, and use computer analyses to uncover common patterns in these responses - … opportunities and gaps in biomedical research that no single nih institute could tackle alone, but that the agency …
Staff
Dr. Goldbach-Mansky is an adjunct investigator in NHGRI's Medical Genetics Branch
… diseases with perinatal onset. the discovery of single gene mutations, which modify the regulation of … dr. goldbach-mansky conducts clinical phenotyping, genetic analyses and characterization of the immunophenotype to … autoinflammatory disease reloaded: a clinical perspective. cell, 140(6):784-90. 2010. [ pubmed ] almeida mq, tsang km, …
News Release
NIH researchers have created a data resource show how differences in an individual's genome can affect gene activity and contribute to disease.
… dna instructions. investigators focused much of their analyses on samples from the nine most available tissue … tibial artery and nerve. the genomic blueprint of every cell is the same, but what makes a kidney cell different from … opportunities and gaps in biomedical research that no single nih institute could tackle alone, but that the agency …
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… and component-specific strategies for data collection and analyses •To plan tests to characterize strengths, synergies, … Function and Phenotype (UM1)•Mapping: RFA-HG-20-045: Single-cell Profiling of Regulatory Element and Gene Activity in …
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… an atlas of tissue gene expression on bulk tissues and single cells in pediatric populations. Create and make … collection (blood, bulk tissue) • Assays (genomic, single cell ) • Special brain consideration 10 11 Tissue Procurement … Coordinating Center Data Analysis and Management • Basic analyses • Genotyping and gene expression analysis at tissue …
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… tools to enhance data utility ¥   Make data, tools, analyses and assembled encyclopedia freely available 4 … associated with specific functional elements in expanded cell space Funding : U54s, 6-8 centers, $20M TC/year, 4 years … funded separately with expectation of functioning as single entity ¥  DCC activities significantly expanded ¥  DAC …
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… the utility of the data; and • make the data, tools, analyses and assembled e ncyclopedia freely available to the … develop a scientifically - based strategy for bounding the cell space to be studied, and to organize and facilitate … and coordinate their activities so as to function as a single entity, as is the case in the current EDCAC …
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… enable:   single cell  methods for genomic technologies discussed here,   …  transcriptome analysis, and   genome‐wide functional  analyses .    … microarrays, defined common human haplotypes,  single  molecule sequencing,  and many more  …
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… ,#through# sharing#ENCODE#data #and#analyses#in# an#unrestricted#manner.#The# … ¥ Systematic#mapping#in#diverse#cell# fates#and#cell#states#continues#to#be# of#high#value# ¥ … to#genes# ¥ New#assays#are#needed#to#map#new# features # ¥ Single#cell/ low#cell#number#assays# are#urgently#needed# ¥ …