Cristina M. Lanata, M.D.
Genomics of Autoimmune Rheumatic Disease Section
M.D. Universidad Peruana Cayetano Heredia, Lima, Peru
Biography
Dr. Lanata attended medical school at the Universidad Peruana Cayetano Heredia in Lima, Peru. From 2008-2009 she worked as a Senior Research Assistant at the Hopkins Lupus Center. Dr. Lanata completed her residency in Internal Medicine at the Georgetown University, Washington Hospital Center (2012); fellowship in Rheumatology at the University of California, San Francisco (2016). She also served as the Chief Resident at the Georgetown University (2012-2013). From 2016-2021, she worked as an Assistant Professor of Medicine, in the Division of Rheumatology at the University of California, San Francisco. Dr Lanata received the Scientist Development Award (2017); the Gilead Sciences Scholar in Rheumatology Award (2020); the NIH Diversity supplement R01 award (2020); and the Investigator Award (2021) from the Rheumatology Research Foundation. In 2021, Dr. Lanata joined the Genomics of Autoimmune Rheumatic Disease Section, at NHGRI.
She is an expert in population genomics in the field of autoimmunity with expertise in Systemic Lupus Erythematosus (SLE), with national and international recognition. She has extensive experience with patient cohorts, and was a Co-Investigator for the California Lupus Epidemiology Study, which yielded multiple collaborative transdisciplinary research projects. She currently serves on the SLE Gene Curation Expert Panel for ClinGen, Clinical Genome Resource, whose purpose is to create an authoritative central resource that defines the clinical relevance of genes and variants for use in precision medicine and research. She was awarded a mini sabbatical for outreach and collaboration at NHGRI (2023). This endeavor proved successful in establishing new partnerships for future studies, further amplifying the reach and impact of her research initiatives.
Scientific Summary
Dr Lanata is a physician-scientist with a primary research focus on exploring the interplay of genetic ancestry, genomics, and environmental influences in the context of Systemic Lupus Erythematosus (SLE) outcomes, with a particular emphasis on addressing health disparities. Within the Genomics of Autoimmune Rheumatic Disease Section, she leads a multi-omics translational research on the potential of whole blood DNA methylation as a useful biomarker for SLE disease heterogeneity and the use of integrative multi-omics to disentangle the environmental and genetic effects of disease risk and outcomes.
In addition, as there is an unmet need to understand the genetic architecture of autoimmunity in the Americas, Dr. Lanata is building collaborations with geneticists and clinicians in Peru to bring genomics to an understudied population that could yield insights into autoimmunity in general.
Publications
Lanata CM, Nititham J, Taylor KE, Solomon O, Chung SA, Blazer A, et al. The dynamics of methylation of CpG sites associated with SLE subtypes in a longitudinal cohort. Arthritis Rheumatol. 2022 Oct;74(10):1676-1686.
Yavuz S, Pucholt P, Sandling JK, Bianchi M, Leonard D, Bolin K, Imgenberg-Kreuz J, Eloranta ML, Kozyrev SV, Lanata CM, Jönsen A, et al. Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease. Lupus Sci Med. 2022 Nov;9(1):e000752.
Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, Sun Y, Ogorodnikov A, Bueno R, Lu A, Thompson M, Rappoport N, Dahl A, Lanata CM, Matloubian M, et al. Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus. Science 2022 Apr 8;376(6589):eabf1970.
Andreoletti G, Lanata CM, Trupin L, Paranjpe I, Jain TS, Nititham J, et al. Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures. Commun Biol. 2021 Apr 21; 4(1):488.
Lanata CM, Blazer A, Criswell LA. The contribution of genetics and epigenetics to our understanding of health disparities in rheumatic diseases. Rheum Dis Clin North Am 2021 Feb;47(1):65-81.
DeQuattro K, Trupin L, Murphy LB, Rush S, Criswell LA, Lanata CM, Dall'Era M, et al. High disease severity among asians in a US multiethnic cohort of individuals with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 2022 Jun;74(6):896-903.
Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, et al. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2019 Aug 29;10(1):3902.
Lanata CM, Chung SA, Criswell LA. DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity. Lupus Sci Med. 2018; 5(1):e000285.
Lanata CM, Nitiham J, Taylor K, Chung SA, Torgerson D, Seldin M, et al. Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients. PLoS One. 2018 Jun 28;13(6):e0199003.
Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata C, Gate RE, et al. Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Nat Biotechnol. 2018 Jan; 36(1):89-94.
Last updated: December 5, 2023