Program Director

Division of Genomic Medicine

Education

M.S. Howard University, 1999

Ph.D. Howard University, 2001

Biography

Dr. Madden is a program director in the Division of Genomic Medicine, National Human Genome Research Institute (NHGRI). Prior to joining NHGRI in 2009, she served as a research geneticist at the National Heart Lung and Blood Institute (NHLBI) from 2002-2006 and chief of staff of the Office of the Director, National Institute of Environmental Health Sciences (NIEHS) from 2006-2009. Her research portfolio includes the Implementing Genomics in Practice (IGNITE) Network, and H3Africa, CSER , the Dissemination and Implementation Research in Health Program, the Fogarty Bioethics Training program, the NIMHD Transdisciplinary Collaborative Centers for Health Disparities Research Program (TCC), and the Jackson Heart Study.

Dr. Madden received her B.S. in Biology from the University of North Carolina at Chapel Hill, her M.S. in Genetic Counseling and her Ph.D. in Genetics and Human Genetics from Howard University. Her research interests include population genomics, genomic medicine, complex disease and health disparities.

Publications

Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg G. Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE. Network.Genet Med. 2018 [PubMed]

Orlando LA, Sperber NR, Voils C, Nichols M, Myers RA, Wu RR, Rakhra-Burris T, Levy KD, Levy M, Pollin TI, Guan Y, Horowitz CR, Ramos M, Kimmel SE, McDonough CW, Madden EB, Damschroder LJ. Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working. Group.Genet Med. 20(6):655-663. 2018. [PubMed]

Williams SR, Hsu FC, Keene KL, Chen WM, Nelson S, Southerland AM, Madden EB, Coull B, Gogarten SM, Furie KL, Dzhivhuho G, Rowles JL, Mehndiratta P, Malik R, Dupuis J, Lin H, Seshadri S, Rich SS, Sale MM, Worrall BB; METASTROKE, The Genomics and Randomized Trials Network (GARNET) Collaborative Research Group; METASTROKE The Genomics and Randomized Trials Network GARNET Collaborative Research Group. Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Neurology. 86(4):351-9. doi: 10.1212/WNL.0000000000002319. 2016. [PubMed]

Sperber NR, Carpenter JS, Cavallari LH, J Damschroder L, Cooper-DeHoff RM, Denny JC, Ginsburg GS, Guan Y, Horowitz CR, Levy KD, Levy MA, Madden EB, Matheny ME, Pollin TI, Pratt VM, Rosenman M, Voils CI, W Weitzel K, Wilke RA, Ryanne Wu R, Orlando LA. Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network. BMC Med Genomics. 10(1):35. doi: 10.1186/s12920-017-0273-2. 2016. [PubMed]

Weitzel KW, Alexander M, Bernhardt BA, Calman N, Carey DJ, Cavallari LH, Field JR, Hauser D, Junkins HA, Levin PA, Levy K, Madden EB, Manolio TA, Odgis J, Orlando LA, Pyeritz R, Wu RR, Shuldiner AR, Bottinger EP, Denny JC, Dexter PR, Flockhart DA, Horowitz CR, Johnson JA, Kimmel SE, Levy MA, Pollin TI, Ginsburg GS; IGNITE Network. The IGNITE network: a model for genomic medicine implementation and research. BMC Med Genomics. 2016 Jan 5;9:1. doi: 10.1186/s12920-015-0162-5. [PubMed]

H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez-Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Fowler, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc'Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori-Acquah SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu-Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange-Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H. Research capacity. Enabling the genomic revolution in Africa. Science. 344(6190):1346-8. doi: 10.1126/science.1251546. 2014. [PubMed]

Keene KL, Chen WM, Chen F, Williams SR, Elkhatib SD, Hsu FC, Mychaleckyj JC, Doheny KF, Pugh EW, Ling H, Laurie CC, Gogarten SM, Madden EB, Worrall BB, Sale MM. Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the vitamin intervention for stroke prevention (VISP) trial. Front Public Health, 2:112. 2014. [PubMed]

Ramos EM, Din-Lovinescu C, Bookman EB, McNeil LJ, Baker CC, Godynskiy G, Harris EL, Lehner T, McKeon C, Moss J, Starks VL, Sherry ST, Manolio TA, Rodriguez LL. A mechanism for controlled access to GWAS data: experience of the GAIN data access committee. Am J Hum Gene, 92(4):479-88. 2013. [PubMed]

Bookman EB, Din-Lovinescu C, Worrall BB, Manolio TA, Bennett SN, Laurie C, Mirel DB, Doheny KF, Anderson GL, Wehr K, Weinshilboum R, Chen DT; for GARNET. Incidental genetic findings in randomized clinical trials: recommendations from the Genomics and Randomized Trials Network (GARNET). Genome Med, 5(1):7. 2013 Jan 30. [PubMed]

Bookman EB, McAllister K, Gillanders E, Wanke K, Balshaw D, Rutter J, Reedy J, Shaughnessy D, Agurs-Collins T, Paltoo D, Atienza A, Bierut L, Kraft P, Fallin MD, Perera F, Turkheimer E, Boardman J, Marazita ML, Rappaport SM, Boerwinkle E, Suomi SJ, Caporaso NE, Hertz-Picciotto I, Jacobson KC, Lowe WL, Goldman LR, Duggal P, Gunnar MR, Manolio TA, Green ED, Olster DH, Birnbaum LS; NIH GxE Interplay Workshop participants. Gene-environment interplay in common complex diseases: forging an integrative model-recommendations from an NIH workshop. Genet Epidemiol, 35(4):217-25. 2011 May. [PubMed]

Kennedy BM, Harsha DW, Bookman EB, Hill YR, Rankinen T, Rodarte RQ, Murla CD. Challenges to recruitment and retention of African Americans in the gene-environment trial of response to dietary interventions (GET-READI) for heart health. Health Education Research, 26(5):923-36. 2011 Oct. [PubMed]

RR Fabsitz, A McGuire, RR Sharp, M Pandey, LM Beskow, LG Biesecker, E Bookman, W Burke, EG Burchard, G Church, EW Clayton, JH Eckfeldt, CV Fernandez, R Fisher, SM.Fullerton, S Gabriel, F Gachupin, C James, GP Jarvik, R Kittles, JR Leib, C O'Donnell, PP O'Rourke, LL Rodriguez, SD Schully, AR Shuldiner, RKF Sze, JV Thakuria, SM Wolf, and GL Burke. Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from an NHLBI working group. Circulation: Cardiovascular Genetics: Journal of the Heart Associations, Vol. 3, No. 6, pp. 574-580. 2010. [PubMed]

E. Bookman, A. Langehorne, J. Eckfeldt, K. Glass, G. Jarvik, M. Klag, G. Koski, A. Motulsky, B. Wilfond, T. Manolio, R. Luepker. Reporting genetic results in research studies: summary and recommendations of an NHLBI working group. Am J of Med Genet, 140(10):1033-40. 2006. [PubMed]

E. Bookman, R. Taylor, L. Adams-Campbell, R. Kittles. DRD4 promoter SNPs and gender effects on extraversion in African Americans, Mol Psychiatry. 7(7):786-9. 2002. [PubMed]

Last updated: February 15, 2019