Program Director Genome Analysis

Division of Genome Sciences

Education

B.A. University of Pennsylvania, 1979

Ph.D. Yale University, 1986

Biography

Dr. Elise A. Feingold is a Program Director in Genome Analysis at the National Human Genome Research Institute (NHGRI). She received a B.A. in biology from the University of Pennsylvania and a Ph.D. in Human Genetics from Yale University. She completed post-doctoral research at the National Heart, Lung, and Blood Institute.

Following a one-year training experience in National Institutes of Health (NIH) extramural programs as a grants associate, Dr. Feingold joined the extramural division of what is now the National Human Genome Research Institute in 1992. Since that time, her area of focus has been on gene discovery, gene expression and functional genomics.

From its inception until 2004, Dr. Feingold managed, in collaboration with the National Cancer Institute, the Mammalian Gene Collection project, which created a comprehensive collection of sequence verified full-length human and mouse cDNA clones.

Dr. Feingold currently leads the Encyclopedia of DNA Elements (ENCODE) and the related project in model organisms (modENCODE) to identify all of the functional elements in the human, and the D. melanogaster and C. elegans genomes, respectively. In addition, Dr. Feingold manages a portfolio of research grants in functional genomics including several Centers of Excellence in Genomic Sciences (CEGS). Dr. Feingold serves on the NIH Common Fund Epigenomics and High Risk - High Reward working groups.

Publications

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T et al. (Mouse ENCODE Consortium) A comparative encyclopedia of DNA elements in the mouse genome. Nature, 515(7527):355-64. doi: 10.1038/nature13992. 2014.

Boyle AP, Araya CL, Brdlik C, Cayting P, Cheng C, Cheng Y et al. Comparative analysis of regulatory information and circuits across distant species. Nature, 512(7515):453-6. doi: 10.1038/nature13668. 2014.

Ho JW, Jung YL, Liu T, Alver BH, Lee S, Ikegami K et al. Comparative analysis of metazoan chromatin organization. Nature, 512(7515):449-52. doi: 10.1038/nature13415. 2014.

Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB et al. (modENCODE Consortium) Comparative analysis of the transcriptome across distant species. Nature, 512(7515):445-8. doi: 10.1038/nature13424. 2014.

Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK et al. Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A, 111(17):6131-8. doi: 10.1073/pnas.1318948111. 2014.

ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 489(7414):57-74. doi: 10.1038/nature11247. 2012.

Mouse ENCODE Consortium, Stamatoyannopoulos JA, Snyder M, Hardison R, Ren B, Gingeras T et al. An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol, 13(8):418. doi: 10.1186/gb-2012-13-8-418. 2012.

ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol, 9(4):e1001046. doi: 10.1371/journal.pbio.1001046. 2011.

Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science. 2010 Dec 24;330(6012):1775-87. doi: 10.1126/science.1196914. PMID: 21177976

modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science, 330(6012):1787-97. doi: 10.1126/science.1198374. 2010.

MGC Project Team, Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ et al. The completion of the Mammalian Gene Collection (MGC). Genome Res, 19(12):2324-33. doi: 10.1101/gr.095976.109. 2009.

ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447(7146):799-816. doi: 10.1038/nature05874. 2007.

ENCODE Project Consortium. The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696):636-40. doi: 10.1126/science.1105136. 2004.

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G et al. (Mammalian Gene Collection Project). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res, 14(10B):2121-7. doi: 10.1101/gr.2596504. 2004.

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS et al. (Mammalian Gene Collection Project). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A, 99(26):16899-903. doi: 10.1073/pnas.242603899. 2002.

Strausberg RL, Feingold EA, Klausner RD, Collins FS. The mammalian gene collection. Science, 286(5439):455-7. 1999.

Feingold EA, Penny LA, Nienhuis AW, Forget BG. An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. Genomics, 61(1):15-23. doi: 10.1006/geno.1999.5935. 1999.

Feingold EA, Forget BG. The breakpoint of a large deletion causing hereditary persistence of fetal hemoglobin occurs within an erythroid DNA domain remote from the beta-globin gene cluster. Blood, 74(6):2178-86. 1989.

Tuan D, Feingold E, Newman M, Weissman SM, Forget BG. Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man. Proc Natl Acad Sci U S A, 80(22):6937-41. 1983,

Last updated: September 17, 2018