Work in the Cell Signaling in Immunity Section focuses on signaling pathways in T lymphocytes, with an emphasis on understanding molecules that are affected by primary immunodeficiencies and how they regulate normal immune cell development and function. Researchers in the section take a multidisciplinary approach, using mouse genetics, cell biology, biochemistry and genomics, coupled with studies of infectious disease and immunization, to examine the functions of signaling molecules in T lymphocytes, white blood cells that are important components of the immune system. We complement this work with studies of T cells from patients with genetic primary immunodeficiencies, focusing on understanding the mechanisms leading to cellular dysfunction in these diseases. The overall goals are to understand the pathophysiology of these diseases, but also to provide insight into the normal regulation of the immune system and how T lymphocytes help orchestrate responses to infection and immunization.
Pamela L. Schwartzberg received her B.A. from Princeton University and her M.D. and Ph.D. degrees from the Columbia College of Physicians and Surgeons, Columbia University. During her Ph.D. studies, she worked with Stephen Goff, Ph.D., Columbia University, on studies of retroviral replication and on early studies using homologous recombination to introduce mutations into the germline of mice - work that helped open a new era in mouse genetics. After an internship at Boston Children's Hospital, she did a fellowship with Harold Varmus, M.D., at the National Cancer Institute, working on signaling pathways involving tyrosine kinases as a special fellow of the Leukemia and Lymphoma Society (in collaboration with Michael Lenardo, M.D., National Institute of Allergy and Infectious Diseases).
She started her own laboratory at the National Human Genome Research Institute at the end of 1997 and was promoted to senior investigator with tenure in 2003. Her laboratory's work has centered on the use of genetic, biochemical and cellular studies to understand T cell signaling, with a focus on pathways affected by primary immunodeficiencies. Dr. Schwartzberg is an adjunct faculty member at the University of Pennsylvania and the George Washington University School of Biomedical Sciences and has received several mentoring awards at NIH. She has served on numerous reviewing and editorial boards and is the recipient of a Searle Scholar's Award, the American Association of Immunologists BD-Pharmingen Biosciences Award for Early Career Scientists and has been elected to the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP).
Last Updated: January 6, 2015