The National Human Genome Research Institute (NHGRI) is organizing a new public research consortium named ENCODE, the Encyclopedia of DNA Elements, to carry out a project to identify all functional elements in the human genome sequence.
A pilot project for testing and comparing existing and new methods to accomplish this goal is the first phase of the ENCODE project. Working together in a highly cooperative effort to rigorously analyze a defined portion of the human genome sequence, investigators with diverse backgrounds and expertise will evaluate the relative merits of each of a diverse set of techniques, technologies and strategies with the goal of identifying a package of approaches that will allow the comprehensive identification of all the functional elements in the human genome sequence. Through the ENCODE pilot, we expect to identify gaps in our ability to annotate genomic sequence and to assess the abilities of different approaches to be scaled up for an effort to analyze the entire human genome.
This process will involve close interactions between computational and experimental scientists to evaluate all possible methods. A set of regions representing approximately 1 percent of the human genome has been selected as the target for this pilot project. By initially concentrating on a limited portion of the human genome, the NHGRI hopes that all of those who have experience and insight into the problem will be willing to participate, whether or not their approaches are proprietary or have already generated proprietary data. The ENCODE consortium will be open to all academic, government and private sector scientists interested in participating in an open process to facilitate the comprehensive interpretation of the human genome sequence and who agree to the criteria for participation that is described below. In this way, the activities of the ENCODE consortium could be influential in helping to guide the planning for a complete public elucidation of functional elements within the entire human genome.
Criteria for participation in the ENCODE consortium are:
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Last Reviewed: March 19, 2012