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1958: Semiconservative Replication of DNA

Illustration of DNA replication

Matthew Meselson and Franklin Stahl demonstrated that DNA replicates semiconservatively, with each strand in a DNA molecule from the parent generation pairing with a new strand in the daughter generation. Each "parent" strand of DNA served as a template for the synthesis of a new strand of DNA.



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Meselson, M., Stahl, F.W. The Replication of DNA in E. coli. Proc Nat Aca Sci USA, 44: 671-682. 1958. [PubMed]


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Last Reviewed: April 23, 2013

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Diagram I of Meselson-Stahl Experiment

Diagram II of Meselson-Stahl Experiment