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The modENCODE Project: Model Organism ENCyclopedia Of DNA Elements (modENCODE)


modENCODE Overview

The modENCODE Project, Model Organism ENCyclopedia Of DNA Elements, was initiated by the funding of applications received in response to Requests for Applications (RFAs) HG-06-006, entitled Identification of All Functional Elements in Selected Model Organism Genomes and HG-06-007, entitled A Data Coordination Center for the Model Organism ENCODE Project (modENCODE). The modENCODE Project is being run as an open consortium and welcomes any investigator willing to abide by the criteria for participation that have been established for the project.

Both computational and experimental approaches are being applied by modENCODE investigators to study the genomes of D. melanogaster and C. elegans. An added benefit of studying functional elements in model organisms is the ability to biologically validate the elements discovered using methods that cannot be applied in humans. The comprehensive dataset that is expected to result from the modENCODE Project will provide important insights into the biology of D. melanogaster and C. elegans as well as other organisms, including humans.

modENCODE Consortium members published the most significant findings from the project so far in two integrative analysis papers that appeared in Science on December 24, 2010. Both the C. elegansPDF fileand D. melanogasterPDF fileintegrative analysis papers are available through open-access. These papers evaluate the success of modENCODE in identifying a comprehensive set of functional genome elements in each species. Several companion papers are also published in Genome Research, Genome Biology, and Nature. Read more about the integrative analysis papers and companion papers.

The modENCODE Data Coordination Center (DCC) maintains databases to track, store, and provide access to data generated as part of the modENCODE Project and other related projects. It maintains browsers for the D. melanogaster and C. elegans genomes and hosts a public website [] that allows members of the scientific community to learn about the modENCODE Project and provide input into the prioritization of certain project activities. The DCC also maintains a data warehouse, modMINE [], that allows sophisticated queries of the modENCODE data.

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Meetings and Workshops

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modENCODE Publications, Features and Press Releases

Press Releases

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modENCODE Consortium Membership

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modENCODE Data Release Policy

NHGRI has designated the modENCODE Project as a community resource project to accelerate access to and use of the data by the entire scientific community. Accordingly, the data release policy is based on the principles of rapid data release to the scientific community set forth in the Fort Lauderdale agreement on Sharing Data from Large-scale Biological Research Projects.

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modENCODE Requests for Application (RFAs)

  • RFA-HG-06-006 []: Identification of All Functional Elements in Selected Model Organism Genomes (Expired)
  • RFA HG-06-007 []: A Data Coordination Center for the Model Organism ENCODE Project (modENCODE) (Expired)

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modENCODE Program Staff

Program Directors

Elise Feingold, Ph.D.

Michael Pazin, Ph.D.

National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305

Phone:(301) 496-7531
Fax:(301) 480-2770

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Last Updated: August 27, 2014

See Also:

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE PDF file
Science, December 24, 2010

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project PDF file
Science, December 24, 2010

Major Findings from the modENCODE project

Unlocking the Secrets of the genome
Nature, June 18, 2009

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On Other Sites:

The modENCODE Project

modMINE data warehouse