NIH

Peter J. McGuire, M.D.

Peter J. McGuire
Physician Scientist
Medical Genomics and Metabolic Genetics Branch

Head
Metabolism, Infection and Immunity Unit


B.A. Villanova University, 1993
M.S. New York Medical College, 1998
M.B.B.Ch. Royal College of Surgeons in Ireland, 2003

T: (301) 451-7716
F: (301) 402-2170
E: mcguirepj@mail.nih.gov
Building 10, Room 7S253
10 CENTER DR, MSC 1646
BETHESDA, MD 20892-1646

Selected Publications


Dr. Peter McGuire received his bachelor's in psychology from Villanova University, a master's. in microbiology and immunology from New York Medical College, and an M.B.B.Ch. (with honors, and equivalent with an M.D.) from the Royal College of Surgeons in Ireland. After completing a combined residency in pediatrics and medical genetics at Mount Sinai Medical Center, he was awarded a fellowship in biochemical genetics from the American College of Medical Genetics and Genzyme. After completing his training, he remained as a junior faculty member in the Program for Inherited Metabolic Diseases at Mount Sinai. Dr. McGuire is board certified in pediatrics, clinical genetics and biochemical genetics.

In 2010, Dr. McGuire moved to the National Institutes of Health (NIH) to join the Physician Scientist Development Program to accelerate his translational research program. Throughout his career, Dr. McGuire has been focused on improving the care of patients with inborn errors of metabolism (IEM). By combining his training in immunology and biochemical genetics, he fashioned a translational research program to understand the interplay between metabolism and the immune system. Through his work he has characterized the morbidity associated with infection in patients with urea cycle disorders, and developed model systems of acute metabolic instability due to infection in IEM.

His NIH Clinical Center protocol, the NIH MINI Study, is the first organized effort to study immune function in patients with IEM, which aims to demonstrate that these patients can be informative regarding the role of intermediary metabolism in immune cell activation and differentiation.     

Scientific Summary

Mcguire Lab Member
Tatiana Tarasenko, M.D., Ph.D.

Clinical Protocol Coordinator
Janet Shiffer, M.S.N., C-R.N.P.

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Posted: November 25, 2014