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Advanced Genomic Technology Development Meeting

May 22-25, 2017
Northeastern University
Boston, Massachusetts

DNA Sequencing

On May 22 - 25, 2017, the National Human Genome Research Institute (NHGRI) hosted the Advanced Genomic Technology Development Meeting at Northeastern University in Boston, Massachusetts. 

The meeting served as an open forum for NHGRI Genomic Technology Program grantees and other scientists and engineers to exchange knowledge and discuss key scientific and technical challenges. The purpose of facilitating these discussions is to advance a broad set of genomic technologies including those for nucleic acid sequencing. 

Monday, May 24, 2018

4:00 p.m.

Registration and Informal Poster Session

5:20 p.m.

Brief Introduction
Mike Smith

5:30 p.m.

CMOS-integrated solid-state nanopore platform for high-bandwith DNA translocation measurements
Ken Shepard

6:00 p.m.

Towards single molecule RNA sequencing using recognition tunneling
Stuard Lindsay

6:30 p.m.

High-throughput genetic interaction sequencing in mammalian cells
Sasha Levy

7:00 p.m.

Towards single-molecule RNA sequencing by recognition tunneling
Martha Bulyk

7:30 p.m.

Evening Snack and then adjourn for the day


Tuesday, May 23, 2018

7:30 a.m.

Breakfast and Registration

   8:10 a.m. Welcome
Mike Smith and Carolyn Hutter

Session Chair: Meni Wanunu

8:25 a.m.

Achieving single nucleotide resolution to enable DNA flossing through alpha-hemolysin
Anna Schibel

8:55 a.m.

Nanopore arrays with stabilized bilayers
Reza Ghadiri

9:25 a.m.

Towards high accuracy nanopore sequencing
Jens Gundlach

9:55 a.m.


10:20 a.m.

Single-molecule electronic measurements of DNA polymerase I attached to carbon nanotube transistors
Philip Collins

10:50 a.m.

Modeling macromolecular transport through protein channels and nanopores
Murugappan Muthukumar

11:20 a.m.

Plasmonic nanopores for trapping, controlling displacement, and sequencing of DNA
Aleksei Aksimentiev

11:50 a.m. Direct picogram DNA and RNA sequencing using nanopore zero-mode waveguides
Meni Wanunu

12:20 p.m.

Lunch and Poster Session I
(Mon PM & Tues AM speakers and odd numbered poster presenters at boards 12:45-1:35pm)

Session Chair: Carolyn Hutter

1:55 p.m.

Sequencing by synthesis in nanogaps using water-soluble polymers as electrical tags
Serge Lemay 

2:25 p.m.

Multidimensional epigenomic single cell analysis
Chongyuan Luo

2:55 p.m.

Cell type-specific mouse brain methylomes profiled using an ultralow-input microfluidic device
Chang Lu

3:25 p.m.

Joshua Weinstein

3:55 p.m. Group Photo and Break
4:25 p.m. Poster Session II
(Tues PM & Wed AM speakers and even numbered poster presenters at boards)

5:15 p.m.

Lead into discussion: Dreaming Big - What makes you think you can do that?
Meni Wanunu

5:35 p.m.

Lead into discussion: Dreaming Big - What makes you think you can do that?
John Nelson

5:55 p.m.

Discussion Q&A

6:30 p.m. Northeastern Reception

Wednesday, May 24, 2018


7:30 a.m.


Session Chair: Serge Lemay

8:15 a.m.

Nanofluidic platforms for high resolution mapping of genomic DNA
J. Michael Ramsey

8:45 a.m.

Technologies for complete human genome sequencing
Jeremy Edwards

9:15 a.m.

Allele-specific enrichment and depletion of nucleic acid variants
David Yu Zhang

9:45 a.m.

Highly accurate genome sequencing of single cells with SISSOR
Xiaohua Huang

10:15 a.m. Single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array
Carl Fuller

10:45 a.m.


11:20 a.m.

Lead into Discussion: Where does technology need to go from here?
Mark Akeson

11:40 a.m.

Lead into Discussion: Where does technology need to go from here?
Chad Nusbaum

12:00 p.m.

Discussion Q&A and Working Lunch

12:45 p.m.

Break (Prepare for Open Meeting)

1:45 p.m. Welcome/Overview
Mike Smith and Carolyn Hutter
2:00 p.m. Lead into Discussion: Defining and staying on the cutting edge
David Page
2:20 p.m. Lead into Discussion: Defining and staying on the cutting edge 
George Church
2:40 p.m. Lead into Discussion: Defining and staying on the cutting edge
Joe Beechem
3:00 p.m. Discussion Q&A
3:45 p.m. BREAK
4:00 p.m. Recent progress on nanopore sequencing at UC Santa Cruz
Mark Akeson
4:30 p.m. Library-free, targeted sequencing of native gDNA from FFPE samples using Hyb & SeqTM technology - the hybridization based single molecule sequencing system
Joe Beechem
5:00 p.m. Bacterial methylomes
Rich Roberts
6:15 p.m. Northeastern Reception
8:00 p.m. Adjourn for the Day

Thursday, May 25, 2018

7:30 a.m.


Session Chair: Mike Smith

8:30 a.m.

Nanopore enabled exonuclease sequencing
Eric Ervin

9:00 a.m.

High Content Pooled Genomic Sequencing
Paul Blainey

9:30 a.m.

Detecting nucleotide modifications using nanopores sequencing
Winston Timp

10:00 a.m.

Poster Session III (public meeting speakers at posters)

10:45 a.m.

Unlocking the combinatorial epigenetic code at a single-molecule level
Efrat Shema

11:15 a.m.

Expanding the scope of genetic screens using single-cell genomics
Andrew Hill

11:45 a.m.

Producing finished quality sequence of structurally complex genomic regions with SHIMS 2.0
Daniel Bellott

12:15 p.m.

Break and grab lunch for working meal

12:30 p.m.

Renaissance in antibiotic discovery
Slava Epstein

1:00 p.m. Nanopore-based characterization of pyrimidine-tagged RNAs
Anastassia Kanavarioti
1:30 p.m. Closing Discussion
1:45 p.m. Meeting Adjourns

Posted: August 6, 2018