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NIH

Meru Sadhu, Ph.D.

Investigator, Genetic Disease Research Branch
Head, Systems Biology and Genome Engineering Section

Scientific Summary

The Systems Biology and Genome Engineering Section's goal is to systematically understand the effects of genetic differences. Researchers in this section study genetic diversity across an expansive range, such as natural variation between individuals or between species, or novel genetic changes that they create. By studying the functional effects of these variants, section researchers work to learn principles of genome function.

Section researchers use genome engineering to direct activities such as genome editing or recombination, using budding yeast as a model organism. As the space of potential genetic variants is immense, the section's researchers study large numbers of genetic differences in parallel. They do this by using large-scale oligonucleotide synthesis to generate a diversity of instructions targeting desired modifications, in order to generate pools of cells containing thousands of unique genomic changes. In addition to existing genome engineering methods, the section is continually developing new approaches to further expand the genetic space that can be studied.

Posted: October 19, 2018