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Daniel A. Gilchrist, Ph.D.

Program Director

Division of Genome Sciences

Education

Ph.D. Stanford University, 2003

B.S. Purdue University, 1996

Contact Info
BG 6700B RM 3129
6700B ROCKLEDGE DR 6908
BETHESDA MD 20892-6908

Biography

Dr. Daniel Gilchrist joined the National Human Genome Research Institute's Extramural Research Program as a program director in 2014. He manages a portfolio of grants focused on functional genomics and computational genomics and data science. He is also part of the NHGRI team managing the ENCODE project, which aims to identify all functional elements in the human and mouse genomes, and the IGVF consortium, which works towards systematic understanding of the effects of genomic variation on genome function and phenotype.

Prior to joining the National Human Genome Research Institute (NHGRI), Dr. Gilchrist was researcher at the National Institute of Environmental Health Sciences, where he studied mechanisms of gene regulation. 

Dr. Gilchrist received a B.S. in biology from Purdue University, a Ph.D. in biology from Stanford University, and completed postdoctoral research at NIEHS in the Laboratory of Molecular Carcinogenesis. 

  • Biography

    Dr. Daniel Gilchrist joined the National Human Genome Research Institute's Extramural Research Program as a program director in 2014. He manages a portfolio of grants focused on functional genomics and computational genomics and data science. He is also part of the NHGRI team managing the ENCODE project, which aims to identify all functional elements in the human and mouse genomes, and the IGVF consortium, which works towards systematic understanding of the effects of genomic variation on genome function and phenotype.

    Prior to joining the National Human Genome Research Institute (NHGRI), Dr. Gilchrist was researcher at the National Institute of Environmental Health Sciences, where he studied mechanisms of gene regulation. 

    Dr. Gilchrist received a B.S. in biology from Purdue University, a Ph.D. in biology from Stanford University, and completed postdoctoral research at NIEHS in the Laboratory of Molecular Carcinogenesis. 

Publications

Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Mol Cell, 52:517-28. 2013. [PubMed]

Gilchrist DA, Fromm G, dos Santos G, Pham LN, McDaniel IE, Burkholder A, Fargo DC, Adelman K. Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev, 26:933-44. 2012. [PubMed]

Gilchrist DA, dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell, 143:540-51. 2010. [PubMed]

Gilchrist DA, Nechaev S, Lee C, Ghosh SKB, Collins J, Gilmour DS, Adelman K. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev, 22:1921-33. 2008. [PubMed]

Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. Nat Genet, 39:1507-11. 2007. [PubMed]

  • Publications

    Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K. Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals. Mol Cell, 52:517-28. 2013. [PubMed]

    Gilchrist DA, Fromm G, dos Santos G, Pham LN, McDaniel IE, Burkholder A, Fargo DC, Adelman K. Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev, 26:933-44. 2012. [PubMed]

    Gilchrist DA, dos Santos G, Fargo DC, Xie B, Gao Y, Li L, Adelman K. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell, 143:540-51. 2010. [PubMed]

    Gilchrist DA, Nechaev S, Lee C, Ghosh SKB, Collins J, Gilmour DS, Adelman K. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev, 22:1921-33. 2008. [PubMed]

    Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K. RNA polymerase is poised for activation across the genome. Nat Genet, 39:1507-11. 2007. [PubMed]

Related Projects

ACTGs
Research Funding
The Encyclopedia of DNA Elements (ENCODE)
DNA sequence
Research Funding
Computational Genomics and Data Science Program

Last updated: June 27, 2022