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Talking Glossary of Genetic Terms

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Elliott Margulies, Ph.D. defines Promoter

Promoter

A promoter is a sequence of DNA needed to turn a gene on or off. The process of transcription is initiated at the promoter. Usually found near the beginning of a gene, the promoter has a binding site for the enzyme used to make a messenger RNA (mRNA) molecule.

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Promoter

A promoter is a sequence of DNA needed to turn a gene on or off. The process of transcription is initiated at the promoter. Usually found near the beginning of a gene, the promoter has a binding site for the enzyme used to make a messenger RNA (mRNA) molecule.

Narration Transcription

The promoter region is the sequence typically referred to that's right upstream or right next to where a gene is about to be transcribed. It's the region where certain regulatory elements will bind; these are proteins that will bind to help RNA get transcribed. Now, "promoter", the term "promoter", can actually be a little bit of a nebulous term because it's not very exact. There are specific sequences that are generally found within a promoter region, but sometimes people refer to even extended promoter region that might include sequences that are farther upstream of the gene that might help enhance or repress the particular gene that's about to be transcribed in certain cell types. In general, if you think of the promoter as that piece of DNA that's just upstream of the transcription start site of a gene, that's pretty much what we refer to as promoters.


Doctor Profile

Elliott Margulies, Ph.D.

Elliott Margulies, Ph.D.

Occupation
Investigator, Genome Technology Branch; Head, Genome Informatics Section

Biography
Dr. Margulies develops bioinformatical approaches to identifying and characterizing regions of the human genome that are evolutionarily conserved across multiple species. The conservation of these sequences over millions of years of evolution is strong evidence that they play important roles in biology, such as coding for genes or functioning as regulatory elements. He has played an important role in advancing the goals of the NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program. Dr. Margulies's group utilizes both high-performance computational analyses and laboratory-based high-throughput genomic methods to decipher the genetic information that confers biological function.

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