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Leslie G. Biesecker, M.D. defines RNA (Ribonucleic Acid)

RNA (Ribonucleic Acid)

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Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), uracil (U), cytosine (C), or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). More recently, some small RNAs have been found to be involved in regulating gene expression.

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RNA (Ribonucleic Acid)

Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), uracil (U), cytosine (C), or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). More recently, some small RNAs have been found to be involved in regulating gene expression.

Narration Transcription

RNA, or ribonucleic acid, is a nucleic acid that is similar in structure to DNA but different in subtle ways. The cell uses RNA for a number of different tasks, one of which is called messenger RNA, or mRNA. And that is the nucleic acid information molecule that transfers information from the genome into proteins by translation. Another form of RNA is tRNA, or transfer RNA, and these are non-protein encoding RNA molecules that physically carry amino acids to the translation site that allows them to be assembled into chains of proteins in the process of translation.


Doctor Profile

Leslie G. Biesecker, M.D.

Leslie G. Biesecker, M.D.

Occupation
Chief and Senior Investigator, Genetic Disease Research Branch; Head, Human Development Section and Physician Scientist Development Program

Biography
Dr. Biesecker's research focuses on the clinical and molecular delineation of human malformation syndromes. Currently, his laboratory is working on two classes of disorders, classic multiple congenital anomaly syndromes and segmental overgrowth disorders. The goals of his research program are to improve the medical care of patients affected by these disorders, provide generalized knowledge about the broad field of birth defects, and better understand basic mechanisms of normal and abnormal human development. Dr. Biesecker's group studies several multiple congenital anomaly syndromes, including Pallister-Hall syndrome, McKusick-Kaufman syndrome, Bardet-Biedl syndrome and Lenz microphthalmia syndrome.

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