Research Funding Opportunities

To apprise the community of research areas that support that mission, NHGRI periodically publishes funding opportunities in the NIH Guide for Grants and Contracts. For your convenience, we have also listed the funding opportunities related to NHGRI on this webpage. NHGRI welcomes innovative investigator-initiated applications and encourages investigators with novel ideas to discuss potential applications with program staff during the concept development stage of the application. If you are considering applying for a Program Announcement with special review (PAR) , a Request for Applications (RFA), or an application that exceeds $500K in direct cost in any one year, we encourage you to review the Guidance to Potential Applicants for NHGRI Support.

For how NHGRI will treat new and non-competing applications, see the FY2022 Funding Policy.

• NOT-HG-23-021: Notice of Participation of the National Human Genome Research Institute (NHGRI) in PA-20-163: Competing Revisions to Existing NIH Grants and Cooperative Agreements (Clinical Trial Optional)

• NOT-HG-23-020: Notice of NHGRI Participation in the National Science Foundation Molecular Foundations for Biotechnology (MFB) Partnerships to Transform Emerging Industries - RNA Tools/Biotechnology

• NOT-HG-23-019: Notice of NHGRI Participation in NOT-OD-23-044 "Notice of Special Interest (NOSI): Support for existing data repositories to align with FAIR and TRUST principles and evaluate usage, utility, and impact”

• PAR-23-085: Genomic Community Resources (U24 Clinical Trial Not Allowed)
  Application Due Dates: January 25, 2023
  Expiration Date: January 26, 2023

• RFA-HG-22-026: Diversity Centers for Genome Research (U54 Clinical Trials Optional)
  Application Due Dates: December 6, 2022; June 23, 2023; June 24, 2024
  Expiration Date: June 25, 2024
  
  NOT-HG-23-015: Notice of Change in Application and Submission Information-Page Limitations to RFA-HG-22-026: Diversity Centers for Genome Research (U54 Clinical Trials Optional)

• RFA-HG-22-027: Diversity Centers for Genome Research (UG3/UH3 Clinical Trials Optional)
  Application Due Dates: December 6, 2022; June 23, 2023; June 24, 2024
  Expiration Date: June 25, 2024

• RFA-HG-22-020: Limited Competition: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) (U24 Clinical Trial Not Allowed)
  Application Due Dates: December 2, 2022
  Expiration Date: December 3, 2022

• RFA-HG-22-021: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed)
  Application Due Dates: December 2, 2022
  Expiration Date: December 3, 2022
  
  NOT-HG-23-003: Notice of Pre-Application Webinar for the NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed) (RFA-HG-22-021)

• RFA-HG-22-008: Multi-Omics for Health and Disease - Disease Study Sites (U01 Clinical Trial Optional)
  Application Due Dates: November 18, 2022
  Expiration Date: November 19, 2022
  
  NOT-HG-23-006: Notice of Change in the Number of Disease Study Sites (DSSs) in RFA-HG-22-008 “Multi-Omics for Health and Disease - Disease Study Sites (U01 Clinical Trial Optional)”

• RFA-HG-22-009: Multi-Omics for Health and Disease - 'Omics Production Centers (U01 Clinical Trial Not Allowed)
  Application Due Dates: November 18, 2022
  Expiration Date: November 19, 2022
  
  NOT-HG-23-007: Notice of Change in the Number of Disease Study Sites (DSSs) in RFA-HG-22-009 “Multi-Omics for Health and Disease - 'Omics Production Centers (U01 Clinical Trial Not Allowed)”

• RFA-HG-22-010: Multi-Omics for Health and Disease - Data Analysis and Coordination Center (U01 Clinical Trial Not Allowed)
  Application Due Dates: November 18, 2022
  Expiration Date: November 19, 2022
  
  NOT-HG-23-008: Notice of Change in the Number of Disease Study Sites (DSSs) in RFA-HG-22-010 “Multi-Omics for Health and Disease - Data Analysis and Coordination Center (U01 Clinical Trial Not Allowed)”
  
  NOT-HG-22-034: Notice of Pre-Application Webinar for Multi-Omics for Health and Disease (RFA-HG-22-008; RFA-HG-22-009; and RFA-HG-22-010)

• Centers of Excellence in Genomic Science (RM1 Clinical Trial Optional)
  PAR-22-107
  Application Receipt Date(s): June 21, 2024
  Expiration Date: June 22, 2024
  
  NOT-HG-23-012: Notice of Need to Expire and Reissue PAR-22-107-“Centers Of Excellence In Genomic Science (RM1 Clinical Trial Optional)” To Clarify Review Criteria For The Resource Sharing Plan

• Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase I: Data Analysis and Validation Centers (U01 Clinical trials not allowed)
  RFA-HG-22-019
  Application Due Dates: November 1, 2022
  Expiration Date: November 2, 2022

• Solicitation of Nominations for the 2022 National Human Genome Research Institute’s Outstanding Award for Enhancing Diversity, Equity, Inclusion, and Accessibility in the Genomics Workforce
  NOT-HG-11-014

• Notice of Intent to Publish a Funding Opportunity Announcement for An Educational Hub for Enhancing Diversity in Computational Genomics and Data Science (U24 Clinical Trials Not Allowed)
  NOT-HG-22-012

• Notice of Early Termination of RFA-HG-21-033, Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (R25 Clinical Trial Not Allowed)
  NOT-HG-22-003

• Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients’ Use of Genomic Information
  NOT-HG-22-011

• Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
  RFA-HG-22-001
  Application Due Dates: March 04, 2022, February 28, 2023, February 27, 2024
  Expiration Date: February 28, 2024

• New Investigators to Promote Workforce Diversity in Genomics, Bioinformatics, or Bioengineering and Biomedical Imaging Research (R01 Clinical Trial Optional)
  RFA-HG-21-041
  Application Due Dates: February 22, 2022; February 22, 2023; February 22, 2024 
  Expiration Date: February 23, 2024 

• Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
  PAR-21-254
  Application Due Dates: February 5, June 5, October 5
  Expiration Date: September 8, 2024

• Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
  PAR-21-255
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: September 8, 2024

• Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial not allowed)
  PAR-21-247
  Application Due Dates: October 1, 2021; June 15, 2022; June 15, 2023
  Expiration Date: June 16, 2023

• Technology Development for Single-Molecule Protein Sequencing (R01 Clinical Trial not allowed)
  RFA-HG-21-001
  Application Receipt Date(s): October 1, 2021; June 15, 2022; June 15, 2023 |
  Expiration Date: June 16, 2023
• Technology Development for Single-Molecule Protein Sequencing (R21 Clinical Trial not allowed)
  RFA-HG-21-002
  Application Receipt Date(s): October 1, 2021; June 15, 2022; June 15, 2023
  Expiration Date: June 16, 2023

• Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application
  NOT-HG-21-018

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial not Allowed)
  RFA-HG-21-006
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R21 Clinical Trial not Allowed)
  RFA-HG-21-007
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44)
  RFA-HG-21-008
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Notice of Special Interest (NOSI): High-throughput Molecular and Cellular Phenotyping
  NOT-HG-21-004

• Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01)
  PAR-20-230
  Application Due Date(s): Applications are accepted by continuous receipt.
  Expiration Date: July 9, 2023
   
• Ethical, Legal and Social Implications (ELSI) (Research R01 Clinical Trial Optional)
  PAR-20-254
  Application Due Dates: October 19 2020, February 17 2021, June 17 2021, October 19 2021, February 17 2022, June 17 2022, October 19 2022, February 17 2023, June 19 2023
  Expiration Date: July 20, 2023
   
• Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21) Clinical Trial Optional)
  PAR-20-255
  Application Due Dates: October 19, 2020, February 17, 2021, June 17, 2021, October 19, 2021, February 17, 2022, June 17, 2022, October 19, 2022, February 17, 2023, June 19, 2023
  Expiration Date: July 20, 2023
   
• Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03) Clinical Trial Optional)
  PAR-20-257
  Application Due Dates: October 19 2020, February 17 2021, June 17 2021, October 19 2021, February 17 2022, June 17 2022, October 19 2022, February 17 2023, June 19 2023
  Expiration Date: July 20, 2023

• Advancing Genomic Medicine Research (Clinical Trial Optional) (R01)
  RFA-HG-20-036
  Due Dates: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023
  Expiration Date: March 14, 2023

• Advancing Genomic Medicine Research (Clinical Trial Optional) (R21)
  RFA-HG-20-037
  Due Dates: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023
  Expiration Date: March 14, 2023

• Genomic Community Resources (U24)
  PAR-20-100
  Application Due Date(s): First due date is May 25, 2020; Standard dates apply after that, by 5:00 PM local time of applicant organization.
  Expiration Date: January 26, 2023
   
• Notice of Special Interest: Genomic Data Repositories (PAR-20-089) and Knowledgebases (PAR-20-097)
  NOT-HG-20-017
   
• Notice of Special Interest: Development of Statistical, Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse Populations
  NOT-HG-20-010
   
• NHGRI Implementation of the NIH Genomic Data Sharing Policy
  NOT-HG-20-011
   
• Notice of New NIH-Designated Data Repository: NHGRI’s Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)
  NOT-HG-19-02

• NIH Directors Pioneer Award Program (DP1 Clinical Trial Optional)
  RFA-RM-23-004
  Application Receipt Date(s): September 8, 2023
  Expiration Date: September 9, 2023
• Research Project Grant (Parent R01 Clinical Trial Required)
  PA-20-183
  Expiration Date: May 8, 2023
• NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  PA-20-185
  Expiration Date: May 8, 2023
• PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  PA-22-176
  Expiration Date: April 6, 2023
• PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
  PA-22-177
  Expiration Date: April 6, 2023
• PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  PA-22-178
  Expiration Date: April 6, 2023
• PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
  PA-22-179
  Expiration Date: April 6, 2023
• NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)
  RFA-RM-22-020
  Application Receipt Date(s): September 1, 2022
  Expiration Date: September 2, 2022
• Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required)
  PAR-21-357
  Expiration Date: January 8, 2025

• Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
  PAR-22-060
  Expiration Date: January 8, 2025

• Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
  PA-21-268 
  Expiration Date: June 30, 2024
   
• NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
  PA-21-151
  Application Receipt Date(s): Multiple dates, see announcement.
  Expiration Date: January 8, 2024
  
  Plans to Promote Safe Environments at Conferences Supported by NIH Grants and Cooperative Agreements
  NOT-OD-22-074
   
• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Admin Supp)
  PA-20-272 
  Application Receipt Date(s): Multiple dates, see announcement.
  Expiration Date: July 24, 2023
  
  Guidance for NHGRI Grantees Requesting Administrative Supplements
   
• Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
  PA-20-275 
  Application Receipt Date(s): A change of grantee organization request must be made before the anticipated start date at the new organization and preferably several months in advance.
  Expiration Date: July 24, 2023
   
• NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
  PA-20-194
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: May 8, 2023
   
• NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  PA-20-195
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: May 8, 2023
   
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) Clinical Trial Not Allowed
  PAR-19-334
   
• Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR®) Standard
  NOT-OD-19-127
   
• Change of Grantee Organization (Type 7 Parent Clinical Trial Optional)
  PA-18-590 
  Application Receipt Date(s): A change of grantee organization request must be made before the anticipated start date at the new organization and preferably several months in advance.
  Expiration Date: January 26, 2021
   
• NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
  PA-19-052

• NOT-OD-23-073: Notice of Special Interest (NOSI): Administrative Supplements to Enhance Software Tools for Open Science

• NOT-OD-23-098: Notice of Special Interest: Administrative Supplements to NIH-funded T32 and TL1 Training Grants to Better Integrate Behavioral and Social Sciences (BSS) with other Health-Related Sciences

• PAR-23-120: Diagnostic Centers of Excellence (X01 Clinical Trial Not Allowed)
  Application Due Date(s): May 15, 2023, May 15, 2024, May 15, 2025
  Expiration Date: May 16, 2025

• PAR-23-122: NIH Director’s Pioneer Award Program (DP1 Clinical Trial Optional)
  Application Due Date(s): September 8, 2023
  Expiration Date: September 9, 2023

• NOT-OD-23-082: Notice of Special Interest (NOSI): Administrative Supplements to Support Collaborations to Improve the AI/ML-Readiness of NIH-Supported Data

• NOT-OD-23-070: Notice of Special Interest (NOSI): Administrative Supplements to Support the Exploration of Cloud in NIH-supported Research
   
• RFA-PM-23-001: Enhancing the Use of the All of Us Research Program’s Data (R21 Clinical Trial Not Allowed)
  Application Due Dates: March 1, 2023
  Expiration Date: March 2, 2023
   
• RFA-PM-23-002: Small Grants to Enhance the Use of the All of Us Research Program’s Data (R03 Clinical Trial Not Allowed)
  Application Due Dates: March 1, 2023
  Expiration Date: March 2, 2023
   
• The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional)
  RFA-OD-22-028
  Application Due Date(s): December 19, 2022, November 22, 2023; November 22, 2024
  Expiration Date: November 23, 2024
   
• Notice of Budget Language Change in RFA-HL-23-016 "New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Coordinating Center (U24 - Clinical Trial Not Allowed)"
  NOT-HL-22-044
   
• Notice of Budget Language Change in RFA-HL-23-015 "New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Clinical/Community Field Centers (UG3/UH3 - Clinical Trial Not Allowed)"
  NOT-HL-22-047
   
• Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional)
  RFA-HD-23-035
  Application Due Date(s): December 5, 2022
  Expiration Date: December 6, 2022
   
• Maternal Health Research Centers of Excellence Data Innovation and Coordinating Hub/Resource Center (U24 Clinical Trial Not Allowed)
  RFA-HD-23-036
  Application Due Date(s): December 5, 2022
  Expiration Date: December 6, 2022
   
• Maternal Health Research Centers of Excellence Implementation Science Hub/Resource Center (U24 Clinical Trial Optional)
  RFA-HD-23-037
  Application Due Date(s): December 5, 2022
  Expiration Date: December 6, 2022
   
• Notice of Special Interest (NOSI): Research on the Health of Sexual and Gender Minority (SGM) Populations
  NOT-MD-22-012
• Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
  PAR-22-105
  Application Due Date(s): June 15, 2022, October 05, 2022, February 05, 2023, June 05, 2023, June 05, 2023, February 05, 2024, June 05, 2024, October 05, 2024, February 05, 2025
  Expiration Date: May 8, 2025
• Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
  PAR-22-106
  Application Due Date(s): June 16, 2022, October 16, 2022, February 16, 2023, June 16, 2023, October 16, 2023, February 16, 2024, June 16, 2024, February 16, 2025, June 16, 2025
  Expiration Date: September 8, 2025
• Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
  PAR-22-109
  Application Due Date(s): June 16, 2022, October 16, 2022, February 16, 2023, June 16, 2023, October 16, 2023, February 16, 2024, June 16, 2024, October 16, 2024
  Expiration Date: February 16, 2025
• International Bioethics Research Training Program (D43 Clinical Trial Optional)
  PAR-22-116
  Application Receipt Date(s): June 6, 2024
  Expiration Date: June 7, 2024
   
• International Research Ethics Education and Curriculum Development Award (R25 Clinical Trial Not Allowed)
  PAR-22-118
  Application Receipt Date(s): June 6, 2024
  Expiration Date: June 7, 2024

• Notice of Intent to Publish a Funding Opportunity Announcement for a Data Management and Coordinating Center for Diagnostic Centers of Excellence (U2C Clinical Trial Not Allowed)
  NOT-NS-22-071

• Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science
  NOT-OD-22-068

• Notice of Special Interest (NOSI): Administrative Supplements to Support Collaborations to Improve the AI/ML-Readiness of NIH-Supported Data
  NOT-OD-22-067

• Notice of Special Interest (NOSI): Support for existing data repositories to align with FAIR and TRUST principles and evaluate usage, utility, and impact
  NOT-OD-22-069

• Notice of Special Interest (NOSI): Administrative Supplements for Advancing the Ethical Development and Use of AI/ML in Biomedical and Behavioral Sciences
  NOT-OD-22-065

• Notice of Special Interest (NOSI): Epidemiologic studies in Asian Americans, Native Hawaiians, and Pacific Islanders (Parent R01 Clinical Trial Not Allowed)
  NOT-HL-23-001

• Notice of Special Interest (NOSI): Administrative Supplement for Research and Capacity Building Efforts Related to Bioethical Issues (Admin Supp Clinical Trial Optional)
  NOT-OD-22-026

• Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
  PA-21-345
  Application Due Dates: Rolling
  Expiration Date: September 10, 2024

• Emerging Global Leader Award (K43 Independent Clinical Trial Required)
  PAR-21-251
  Application Due Dates: November 3, 2021, November 3, 2022, and November 3, 2023
  Expiration Date: December 12, 2023

• Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)
  PAR-21-252
  Application Due Dates: November 3, 2021, November 3, 2022, and November 3, 2023
  Expiration Date: December 12, 2023

• Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications
  NOT-EB-20-017

• Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health
  NOT-EB-21-001
   
• Notice of Intent to Publish a Funding Opportunity Announcement for Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)
  NOT-MD-21-016

• Notice Announcing the National Human Genome Research Institutes Expectation for Sharing Quality Metadata and Phenotypic Data
  NOT-HG-21-022

• Notice of NIH Participation in Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science
  NOT-OD-21-011

• Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science
  NOT-OD-20-073

• Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed)
  PA-20-025
  Application Due Date(s): September 5, January 5, April 5
  Expiration Date: January 6, 2023

• NIH Highlights Support for Data Science Research through the Academic Research Enhancement Award (AREA) Program
  NOT-GM-19-021 
   
• Notice of Special Interest in Research on the Health of Sexual and Gender Minority (SGM) Populations
  NOT-MD-19-001 
   
• National Science Foundation - National Institutes of Health NSF-NIH Interagency Initiative: Smart and Connected Health
  NOT-OD-18-149 
   
• National Science Foundation - National Institutes of Health NSF-NIH Interagency Initiative: Smart and Connected Health 
  NOT-OD-18-149 
   
• Announcing the High-Priority, Short-Term Project Award (R56) 
  • Notice of NHGRI's Participation in NOT-OD-04-047 "High Priority, Short-Term Project Award (R56)" 
    NOT-HG-17-004 [grants.nih.gov]