Research Funding Opportunities

To apprise the community of research areas that support that mission, NHGRI periodically publishes funding opportunities in the NIH Guide for Grants and Contracts. For your convenience, we have also listed the funding opportunities related to NHGRI on this webpage. NHGRI welcomes innovative investigator-initiated applications and encourages investigators with novel ideas to discuss potential applications with program staff during the concept development stage of the application. If you are considering applying for a Program Announcement with special review (PAR) , a Request for Applications (RFA), or an application that exceeds $500K in direct cost in any one year, we encourage you to review the Guidance to Potential Applicants for NHGRI Support.

For how NHGRI will treat new and non-competing applications, see the FY2021 Funding Policy.

• Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Clinical Trial Not Allowed
  RFA-HG-21-036
  Application Due Date: November 1, 2021
  Expiration Date: November 2, 2021

• Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Production Research and Development Centers (UM1 Clinical trials not allowed)
  RFA-HG-21-029
  Application Due Date: November 1, 2021
  Expiration Date: November 2, 2021

• Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Analysis and Validation Centers (U01 Clinical trials not allowed)
  RFA-HG-21-030 
  Application Due Date: November 1, 2021
  Expiration Date: November 2, 2021

• Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Phase 1: Data Resource and Administrative Coordinating Center (U24 Clinical trials not allowed)
  RFA-HG-21-031
  Application Due Date: November 1, 2021
  Expiration Date: November 2, 2021

• Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (R25 Clinical Trial Not Allowed)
  RFA-HG-21-033
  Application Due Dates: December 1, 2021; July 1, 2022; July 1, 2023 
  Expiration Date: July 2, 2023

• New Investigators to Promote Workforce Diversity in Genomics, Bioinformatics, or Bioengineering and Biomedical Imaging Research (R01 Clinical Trial Optional)
  RFA-HG-21-041

• Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
  PAR-21-254
  Application Due Dates: February 5, June 5, October 5
  Expiration Date: September 8, 2024

• Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
  PAR-21-255
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: September 8, 2024

• Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial not allowed)
  PAR-21-247
  Application Due Dates: October 1, 2021; June 15, 2022; June 15, 2023
  Expiration Date: June 16, 2023

• Technology Development for Single-Molecule Protein Sequencing (R01 Clinical Trial not allowed)
  RFA-HG-21-001
  Application Receipt Date(s): October 1, 2021; June 15, 2022; June 15, 2023 |
  Expiration Date: June 16, 2023
• Technology Development for Single-Molecule Protein Sequencing (R21 Clinical Trial not allowed)
  RFA-HG-21-002
  Application Receipt Date(s): October 1, 2021; June 15, 2022; June 15, 2023
  Expiration Date: June 16, 2023

• Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application
  NOT-HG-21-018

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R01 Clinical Trial not Allowed)
  RFA-HG-21-006
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R21 Clinical Trial not Allowed)
  RFA-HG-21-007
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44)
  RFA-HG-21-008
  Application Receipt Dates: June 25, 2021; March 1, 2022; February 1, 2023
  Expiration Date: February 2, 2023

• Notice of Intent to Publish a Funding Opportunity Announcement for New Investigators to Promote Workforce Diversity in Genomics and other Health-Related Research (R01 Clinical Trial Optional)
  NOT-HG-21-024

• Notice of Special Interest (NOSI): High-throughput Molecular and Cellular Phenotyping
  NOT-HG-21-004

• Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01)
  PAR-20-230
  Application Due Date(s): Applications are accepted by continuous receipt.
  Expiration Date: July 9, 2023
• Ethical, Legal and Social Implications (ELSI) (Research R01 Clinical Trial Optional)
  PAR-20-254
  Application Due Dates: October 19 2020, February 17 2021, June 17 2021, October 19 2021, February 17 2022, June 17 2022, October 19 2022, February 17 2023, June 19 2023
  Expiration Date: July 20, 2023
   
• Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21) Clinical Trial Optional)
  PAR-20-255
  Application Due Dates: October 19, 2020, February 17, 2021, June 17, 2021, October 19, 2021, February 17, 2022, June 17, 2022, October 19, 2022, February 17, 2023, June 19, 2023
  Expiration Date: July 20, 2023
   
• Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03) Clinical Trial Optional)
  PAR-20-257
  Application Due Dates: October 19 2020, February 17 2021, June 17 2021, October 19 2021, February 17 2022, June 17 2022, October 19 2022, February 17 2023, June 19 2023
  Expiration Date: July 20, 2023
   

• Advancing Genomic Medicine Research (Clinical Trial Optional) (R01)
  RFA-HG-20-036
  Due Dates: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023
  Expiration Date: March 14, 2023

• Advancing Genomic Medicine Research (Clinical Trial Optional) (R21)
  RFA-HG-20-037
  Due Dates: August 3, 2020; March 8, 2021; November 2, 2021; August 1, 2022; March 13, 2023
  Expiration Date: March 14, 2023

• Genomic Community Resources (U24)
  PAR-20-100
  Application Due Date(s): First due date is May 25, 2020; Standard dates apply after that, by 5:00 PM local time of applicant organization.
  Expiration Date: January 26, 2023
   
• Novel Synthetic Nucleic Acid Technology Development (R01 Clinical Trial not allowed)
  RFA-HG-20-014
  Application Due Date(s): June 24, 2020; February 1, 2021; October 1, 2021; June 24, 2022
  Expiration Date: June 25, 2022
  
  Notice of Change to Receipt Date for RFA-HG-20-014, RFA-HG-20-015, and RFA-HG-20-016: NHGRI Synthetic Nucleic Acid Technology Development FOAs
  NOT-HG-21-005
   
• Novel Synthetic Nucleic Acid Technology Development (R21) (Clinical Trial not allowed)
  RFA-HG-20-015
  Application Due Date(s): June 24, 2020; February 1, 2021; October 1, 2021; June 24, 2022
  Expiration Date: June 25, 2022
   
• Novel Synthetic Nucleic Acid Technology Development (R43/R44) (Clinical Trial Not Allowed)
  RFA-HG-20-016
  Application Due Date(s): June 24, 2020; February 1, 2021; October 1, 2021; June 24, 2022
  Expiration Date: June 25, 2022
   
• Notice of Special Interest: Genomic Data Repositories (PAR-20-089) and Knowledgebases (PAR-20-097)
  NOT-HG-20-017
   
• Notice of Special Interest: Development of Statistical, Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse Populations
  NOT-HG-20-010
   
• Notice of Change: Emphasizing an Opportunity for New Institutional Applicants in Response to PAR-19-204 Centers of Excellence in Genomic Science (RM1 Clinical Trial Optional)
  NOT-HG-20-013
   
• NHGRI Implementation of the NIH Genomic Data Sharing Policy
  NOT-HG-20-011
   
• Notice of New NIH-Designated Data Repository: NHGRI’s Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL)
  NOT-HG-19-02

• PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  PA-21-259
  Expiration Date: April 6, 2022

• PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
  PA-21-260
  Expiration Date: April 6, 2022

  PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
  PA-21-261
  Expiration Date: April 6, 2022

  PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  PA-21-262
  Expiration Date: April 2022

• Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
  PA-21-268 
  Expiration Date: June 30, 2024
   
• NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
  PA-21-151
  Application Receipt Date(s): Multiple dates, see announcement.
  Expiration Date: January 8, 2024
   
• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Admin Supp)
  PA-20-272 
  Application Receipt Date(s): Multiple dates, see announcement.
  Expiration Date: July 24, 2023
  
  Guidance for NHGRI Grantees Requesting Administrative Supplements
   
• Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
  PA-20-275 
  Application Receipt Date(s): A change of grantee organization request must be made before the anticipated start date at the new organization and preferably several months in advance.
  Expiration Date: July 24, 2023
   
• NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
  PA-20-194
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: May 8, 2023
   
• NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  PA-20-195
  Application Due Dates: February 16, June 16, October 16
  Expiration Date: May 8, 2023
   
• NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  PA-19-056
  Application Receipt Date(s): February 5, June 5, October 5
  Expiration Date: January 8, 2022
   
• Research Project Grant (Parent R01 Clinical Trial Required)
  PA-19-055
  Application Receipt Date(s): February 5, June 5, October 5
  Expiration Date: January 8, 2022
   
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) Clinical Trial Not Allowed
  PAR-19-334
   
• Notice of Special Interest: Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Applications Directed at the Adoption of the Fast Healthcare Interoperability Resources (FHIR®) Standard
  NOT-OD-19-127
   
• Change of Grantee Organization (Type 7 Parent Clinical Trial Optional)
  PA-18-590 
  Application Receipt Date(s): A change of grantee organization request must be made before the anticipated start date at the new organization and preferably several months in advance.
  Expiration Date: January 26, 2021
   
• NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
  PA-19-052

•  

  Administrative Supplements to Promote Diversity in Research and Development  Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed)
  PA-21-345
  Application Due Dates: Rolling
  Expiration Date: September 10, 2024

• Emerging Global Leader Award (K43 Independent Clinical Trial Required)
  PAR-21-251
  Application Due Dates: November 3, 2021, November 3, 2022, and November 3, 2023
  Expiration Date: December 12, 2023

• Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)
  PAR-21-252
  Application Due Dates: November 3, 2021, November 3, 2022, and November 3, 2023
  Expiration Date: December 12, 2023

• Notice of Special Interest (NOSI): Synthetic Biology for Biomedical Applications
  NOT-EB-20-017

• Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
  PAR-19-134
  Application Due Dates: Standard Dates
  Expiration Date: January 8, 2022
  
  NHGRI Notice of Participation in PAR-19-134, "Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)"
  NOT-HG-21-021

• Notice of Special Interest (NOSI): Small Business Initiatives for Innovative Diagnostic Technology for Improving Outcomes for Maternal Health
  NOT-EB-21-001
   
• Notice of Intent to Publish a Funding Opportunity Announcement for Understanding and Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional)
  NOT-MD-21-016

• Notice Announcing the National Human Genome Research Institutes Expectation for Sharing Quality Metadata and Phenotypic Data
  NOT-HG-21-022

• Notice of NIH Participation in Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science
  NOT-OD-21-011

• Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions and Administrative Supplements for Research on Coronavirus Disease 2019 (COVID-19) in Individuals with Down Syndrome for the INCLUDE Project
  NOT-OD-20-129

• Notice of Common Funds Participation in PA-20-135 "Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)"
  NOT-RM-20-016

• Notice of NHGRI’s Participation in PA-18-935 "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)"
  NOT-HG-20-034

• Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions for Research on the 2019 Novel Coronavirus
  NOT-HG-20-030

• Notice of Special Interest (NOSI): Availability of Administrative Supplements to Advance Safe and Effective Therapeutics in Pregnant and Lactating Women and Children
  NOT-HD-20-003

• Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional)
  PA-20-135
  Application Due Date(s): See the Emergency Notice of Special Interest (NOSI) for any applicable Application Due Dates.
  Expiration Date: March 10, 2023

• Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science
  NOT-OD-20-073

• Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed)
  PA-20-025
  Application Due Date(s): September 5, January 5, April 5
  Expiration Date: January 6, 2023

• Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)
  PA-20-047
  Application Due Date(s): September 5, January 5, April 5
  Expiration Date: January 6, 2023

• Notice of Special Interest: Administrative Supplements to Promote Research Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars
  NOT-OD-20-054

• Notice of Special Interest (NOSI): Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship Awards to Support Training in Research Related to Down Syndrome as Part of the INCLUDE Project
  NOT-OD-20-020

• Notice of Special Interest (NOSI): Mentored Career Development Awards to Foster the Careers of Investigators Pursuing Research Related to Down syndrome as Part of the INCLUDE Project
  NOT-OD-20-021

• Notice of Special Interest: Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations (Admin Supp Clinical Trial Optional)
  NOT-OD-20-048

• Notice of Special Interest: Administrative Supplements for Research on Sex/Gender Influences (Admin Supp Clinical Trial Optional)
  NOT-OD-20-049

• Notice of NHGRI Participation in PAR-19-372, Social Epigenomics Research Focused on Minority Health and Health Disparities (R01-Clinical Trial Not Allowed)
  NOT-HG-19-026

• Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
  PAR-19-274
  Application Receipt/Submission Date(s): February 5, June 5, October 5
  Expiration Date: May 8, 2022

• Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
  PAR-19-275
  Application Receipt/Submission Date(s): February 16, June 16, October 16
  Expiration Date: May 8, 2022

• Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
  PAR-19-276
  Application Receipt/Submission Date(s): February 16, June 16, October 16
  Expiration Date: May 8, 2022

• NIH Highlights Support for Data Science Research through the Academic Research Enhancement Award (AREA) Program
  NOT-GM-19-021 
   
• Notice of Special Interest in Research on the Health of Sexual and Gender Minority (SGM) Populations
  NOT-MD-19-001 
   
• National Science Foundation - National Institutes of Health NSF-NIH Interagency Initiative: Smart and Connected Health
  NOT-OD-18-149 
   
• National Science Foundation - National Institutes of Health NSF-NIH Interagency Initiative: Smart and Connected Health 
  NOT-OD-18-149 
   
• Announcing the High-Priority, Short-Term Project Award (R56) 
  • Notice of NHGRI's Participation in NOT-OD-04-047 "High Priority, Short-Term Project Award (R56)" 
    NOT-HG-17-004 [grants.nih.gov]