Search Results
Research Funding
The Genomic Variation Program supports large-scale studies of human genetic variation.
… About 99.5 percent of a person's DNA is the same as any unrelated person's DNA. Differences in … explains some of the differences among people, such as eye color and blood group, as well as whether a person has a higher or … Variation Program supports research aimed at: Discovering and typing single nucleotide polymorphisms (SNPs), indels, …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
…  Genomic variation reflects the differences in a person’s DNA compared to other peoples’ DNA.  There are multiple types of variants in human genomes, … subset of genomic variants contributes to human health and disease.  Researchers create reference human genome …
News Release
Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.
… (GTEx) project to explore how human genes are expressed and regulated in different tissues, and the role that genomic variation plays in modulating that … genomic variants - inherited spelling changes in the DNA code - may influence gene activity and lead to disease. …
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells … 1 alpha), a protein that acts as a sensor for oxygen and nutrients in many types of cancer. They discovered 40 new … rays from the sun and from tanning beds can damage the DNA in skin cells, causing melanoma. If melanoma is caught …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… Berlin Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic … Stanford University Stanford Center for Connecting DNA Variants to Function and Phenotype HG011972 Marc Vidal Dana-Farber Cancer … the effects of genomic variation on genome function and how these effects shape phenotypes. The program is based …
Educational Resources
DNA replication is the process by which a molecule of DNA is duplicated.
… DNA Replication … DNA replication is the process by which a molecule of DNA is duplicated. … DNA, Cell Division, Cell Biology … DNA replication is the process by which the genome’s DNA is copied in cells. Before a cell divides, it must first … DNA replication is the process by which a molecule of DNA is …
Educational Resources
DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.
… DNA Sequencing … DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule. … Adenine, Cytosine, Guanine, Thymine, ACGT, DNA, DNA Sequencing … DNA sequencing refers to the general laboratory technique for …
The Genomics Landscape
In the September 3, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about the Impact of Genomic Variation on Function (IGVF) Consortium, the 2020 Genomic Innovator Awards and more.
… Last month, Dr. Sara Hull (NHGRI Bioethics Core Director) and I answered questions about bioethics and genomics research on Twitter as part of #AskDrGenome . … by George Church , Wendy Chung , Jonathan Pritchard , and Carlos Bustamante . Finally, the 91st meeting of the …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical … building blocks - called "bases" - that make up the DNA molecule. … Sequencing DNA means determining the order of the four chemical building … to determine which stretches of DNA contain genes and which stretches carry regulatory instructions, turning …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes. … that a mutation - or alteration - in a particular gene's DNA may contribute to a certain disease. However, it can be … researchers believe that mutations in the genes BRCA1 and BRCA2 cause as many as 60 percent of all cases of …