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News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… doctors, the deadliest enemy is metastasis - the migration of cancer cells from the original tumor to other places in the body. In at least 90 percent of hard-tumor cancer deaths, the killer isn't the original … They have developed transgenic zebrafish as a live animal model of metastasis - offering cancer researchers a …
For Patients and Families
A rare disease is generally considered to be a disease that affects fewer than 200,000 people in the United States at any given time.
… A rare disease is generally considered to be a disease that affects fewer than 200,000 people in the United … diseases are referred to as rare, genetic diseases. Many of these genetic mutations can be passed on from one … a role in rare diseases. Such factors may directly cause disease, or interact with genetic factors to cause or …
News Release
NHGRI will highlight rare disease research that benefits affected patients and provides insights into more common disorders on Rare Disease Day.
… Institute (NHGRI) researchers are highlighting rare disease research that benefits affected patients and also … They are underlining this important relationship in advance of Rare Disease Day at NIH , a day-long symposium that is part of a … Rare disease research may provide insights into common diseases …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
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… Toronto, Canada. She has been at the National Institutes of Health since 1994, first at the National Institute of … to positional cloning to functional genomic analyses using animal models. She has participated in several collaborative … properly functioning splicing machinery in leukemogenesis. Animal models play a critical role in understanding the …
Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… Complex Disease … A complex disease is caused by the interaction of multiple genes and … Genes, Cancer, Heart Disease, Gene-environment Interactions … A complex disease (or condition), when discussed in the context of genetics, reflects a disorder that results from the …
15 Ways Genomics Influences Our World
Genomics is ending diagnostic odysseys for patients with rare diseases.
… with fewer than 200,000 people diagnosed. About 80 percent of these rare disorders are genetic in origin, and 95 percent of them do not have even one treatment approved by the FDA . … has led to substantial advances in discovering the causes of rare disorders. Many families have gone through years of …
For Patients and Families
The Genetic and Rare Diseases Information Center helps people find useful information about genetic and rare diseases.
… Human Genome Research Institute (NHGRI) and the Division of Rare Diseases Research Innovation (DRDRI) at the National … Sciences) - two agencies at the National Institutes of Health (NIH). GARD provides immediate, virtually … and teachers who work with people with a genetic or rare disease. Even scientists who are studying a genetic or rare …
Genetic Disorders
Charcot-Marie-Tooth disease is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles and loss of sensation.
… Charcot-Marie-Tooth disease (CMT) is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes. … disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and …
For Patients and Families
Neglected diseases are conditions that inflict severe health burdens on the world's poorest people.
… severe health burdens on the world's poorest people. Many of these conditions are infectious diseases that are most … private pharmaceutical companies cannot recover the cost of developing and producing treatments for these diseases. … do not cause dramatic outbreaks that kill large numbers of people. Rather, such diseases usually exact their toll …
News Release
NIH recently awarded approximately $6.8 million in grants to several research teams to study the biology of rare and undiagnosed diseases.
… The National Institutes of Health (NIH) recently awarded approximately $6.8 million … in grants to several research teams to study the biology of rare and undiagnosed diseases. The new grants, pending … studies to better understand the causes and development of these diseases, and to improve the ability of doctors to …